Evidence map›Paper›PMID 32314873›Full record

ArticleEMBO reports2020

Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone.

Katie L Owen, Linden J Gearing, Damien J Zanker, Natasha K Brockwell, Weng Hua Khoo, Daniel L Roden, Marek Cmero, Stefano Mangiola, Matthew K Hong, Alex J Spurling and 17 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.

  1. Pooled it
  2. Review
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  5. Review
  6. Interferon-JAK-STAT Axis in Bone Metabolism.Current osteoporosis reports · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Designing nucleic acid-based therapeutics for cancer treatment: Updates on the state of the art.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Review
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  17. Cancer Cell Dormancy in the Bone Microenvironment.Current osteoporosis reports · 2025
    Review
  18. Article
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  20. Review

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 14 institutions in 1 country.

Katie L OwenLa Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, La Trobe University, Melbourne, Vic., Australia.
Linden J GearingCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Vic., Australia.
Damien J ZankerLa Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, La Trobe University, Melbourne, Vic., Australia.
Natasha K BrockwellLa Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, La Trobe University, Melbourne, Vic., Australia.
Weng Hua KhooDivision of Bone Biology, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Daniel L RodenCancer Research Division, The Kinghorn Cancer Centre/Garvan Institute of Medical Research, Sydney, NSW, Australia.
Marek CmeroMurdoch Children's Research Institute, Parkville, Vic., Australia.
Stefano MangiolaBioinformatics Division, The Walter and Eliza Hall Institute, Parkville, Vic., Australia.
Matthew K HongDepartments of Urology and Surgery, Royal Melbourne Hospital, The University of Melbourne, Parkville, Vic., Australia.
Alex J SpurlingLa Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, La Trobe University, Melbourne, Vic., Australia.
Michelle McDonaldCancer Research Division, The Kinghorn Cancer Centre/Garvan Institute of Medical Research, Sydney, NSW, Australia.
Chia-Ling ChanSchool of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, Australia.
Anupama PasamTranslational Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, Vic., Australia.
Ruth J LyonsGenomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Hendrika M DuivenvoordenLa Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, La Trobe University, Melbourne, Vic., Australia.
Andrew RyanTissuePath Specialist Pathology, Mount Waverley, Vic, Australia.
Lisa M ButlerFreemason's Foundation Centre for Men's Health, University of Adelaide Medical School, Adelaide, SA, Australia.
John M MariadasonOlivia Newton-John Cancer Research Institute, Heidelberg, Vic., Australia.
Tri Giang PhanSchool of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, Australia.ORCID 0000-0002-4909-2984
Vanessa M HayesSchool of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, Australia.
Shahneen SandhuCentral Clinical School, University of Sydney, Camperdown, NSW, Australia.
Alexander SwarbrickDivision of Bone Biology, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Niall M CorcoranDepartments of Urology and Surgery, Royal Melbourne Hospital, The University of Melbourne, Parkville, Vic., Australia.
Paul J HertzogCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Vic., Australia.
Peter I CroucherSchool of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, Australia.
Chris HovensDepartments of Urology and Surgery, Royal Melbourne Hospital, The University of Melbourne, Parkville, Vic., Australia.
Belinda S ParkerLa Trobe Institute for Molecular Science, Department of Biochemistry and Genetics, La Trobe University, Melbourne, Vic., Australia.ORCID 0000-0002-8333-1926
Garvan Institute of Medical Research · AULa Trobe University · AUHudson Institute of Medical Research · AUProstate Cancer Foundation of Australia · AUMurdoch Children's Research Institute · AUOlivia Newton-John Cancer Wellness & Research Centre · AUPeter MacCallum Cancer Centre · AUSouth Australian Health and Medical Research Institute · AUThe Royal Melbourne Hospital · AUThe University of Melbourne · AUThe University of Sydney · AUTissuPath · AUUNSW Sydney · AUWalter and Eliza Hall Institute of Medical Research · AU

Funding

Australiian Research Council FT130100671Prostate Cancer Foundation Australia/MovemberVictorian Cancer Agency (VCA) MCRF16022
6 · The paper itself

Abstract

The latency associated with bone metastasis emergence in castrate-resistant prostate cancer is attributed to dormancy, a state in which cancer cells persist prior to overt lesion formation. Using single-cell transcriptomics and ex vivo profiling, we have uncovered the critical role of tumor-intrinsic immune signaling in the retention of cancer cell dormancy. We demonstrate that loss of tumor-intrinsic type I IFN occurs in proliferating prostate cancer cells in bone. This loss suppresses tumor immunogenicity and therapeutic response and promotes bone cell activation to drive cancer progression. Restoration of tumor-intrinsic IFN signaling by HDAC inhibition increased tumor cell visibility, promoted long-term antitumor immunity, and blocked cancer growth in bone. Key findings were validated in patients, including loss of tumor-intrinsic IFN signaling and immunogenicity in bone metastases compared to primary tumors. Data herein provide a rationale as to why current immunotherapeutics fail in bone-metastatic prostate cancer, and provide a new therapeutic strategy to overcome the inefficacy of immune-based therapies in solid cancers.

Indexed as

Bone NeoplasmsProstatic NeoplasmsHumansInterferonsMaleSignal TransductionInterferonsbone metastasisdormancyimmune evasionprostate cancertype I interferon

Identifiers

PMID32314873
PMCPMC7271653
OpenAlexW3016919772

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.