ArticleJournal of medical virology2020
Understanding evolution of SARS-CoV-2: A perspective from analysis of genetic diversity of RdRp gene.
Article in Journal of medical virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The recency and geographical origins of the bat viruses ancestral to SARS-CoV and SARS-CoV-2.Cell · 2025Article
- Rapid evolution leads to extensive genetic diversification of cattle flu Influenza D virus.Communications biology · 2024Article
- Hypovirulence-associated mycovirus epidemics cause pathogenicity degeneration of Beauveria bassiana in the field.Virology journal · 2023Article
- Next-generation nanophotonic-enabled biosensors for intelligent diagnosis of SARS-CoV-2 variants.The Science of the total environment · 2023Review
- The origins of COVID-19 pandemic: A brief overview.Transboundary and emerging diseases · 2022Review
- A comprehensive genomic study, mutation screening, phylogenetic and statistical analysis of SARS-CoV-2 and its variant omicron among different countries.Journal of infection and public health · 2022Article
- Women in the European Virus Bioinformatics Center.Viruses · 2022Article
- Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function.International journal of biological macromolecules · 2022Article
- Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou, China.Science China. Life sciences · 2021Article
- Article
- SARS-CoV-2 Quasispecies Provides an Advantage Mutation Pool for the Epidemic Variants.Microbiology spectrum · 2021Article
- One year into the pandemic: Short-term evolution of SARS-CoV-2 and emergence of new lineages.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021Review
- MSC-derived exosomes carrying a cocktail of exogenous interfering RNAs an unprecedented therapy in era of COVID-19 outbreak.Journal of translational medicine · 2021Review
- UMAP-assisted K-means clustering of large-scale SARS-CoV-2 mutation datasets.Computers in biology and medicine · 2021Article
- Quick overview of diagnostic kits and smartphone apps for urologists during the COVID-19 pandemic: a narrative review.Translational andrology and urology · 2021Review
- Severe acute respiratory syndrome coronavirus-2: implications for blood safety and sufficiency.Vox sanguinis · 2021Review
- SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains.PloS one · 2021Article
- Review
- Understanding evolution of SARS-CoV-2: A perspective from analysis of genetic diversity of RdRp gene.Journal of medical virology · 2020Article
- SARS-CoV-2 infections with emphasis on pediatric patients: a narrative review.Revista do Instituto de Medicina Tropical de Sao Paulo · 2020Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronavirus disease 2019 emerged as the first example of "Disease X", a hypothetical disease of humans caused by an unknown infectious agent that was named as novel coronavirus and subsequently designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The origin of the outbreak at the animal market in Wuhan, China implies it as a case of zoonotic spillover. The study was designed to understand evolution of Betacoronaviruses and in particular diversification of SARS-CoV-2 using RNA dependent RNA polymerase (RdRp) gene, a stable genetic marker. Phylogenetic and population stratification analyses were carried out using maximum likelihood and Bayesian methods, respectively. Molecular phylogeny using RdRp showed that SARS-CoV-2 isolates cluster together. Bat-CoV isolate RaTG13 and Pangolin-CoVs are observed to branch off prior to SARS-CoV-2 cluster. While SARS-CoV form a single cluster, Bat-CoVs form multiple clusters. Population-based analyses revealed that both SARS-CoV-2 and SARS-CoV form separate clusters with no admixture. Bat-CoVs were found to have single and mixed ancestry and clustered as four sub-populations. Population-based analyses of Betacoronaviruses using RdRp revealed that SARS-CoV-2 is a homogeneous population. SARS-CoV-2 appears to have evolved from Bat-CoV isolate RaTG13, which diversified from a common ancestor from which Pangolin-CoVs have also evolved. The admixed Bat-CoV sub-populations indicate that bats serve as reservoirs harboring virus ensembles that are responsible for zoonotic spillovers such as SARS-CoV and SARS-CoV-2. The extent of admixed isolates of Bat-CoVs observed in population diversification studies underline the need for periodic surveillance of bats and other animal reservoirs for potential spillovers as a measure towards preparedness for emergence of zoonosis.
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