Evidence map›Paper›PMID 32314810›Full record

ArticleJournal of medical virology2020

Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

Alberto Paniz-Mondolfi, Clare Bryce, Zachary Grimes, Ronald E Gordon, Jason Reidy, John Lednicky, Emilia Mia Sordillo, Mary Fowkes

3 registry-linked trialsOpen access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 556 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
556citing papers in PubMed, 5 pooled it
79.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04775784 unknown statusnot on this map

Determination of SARS-Cov-2 Virus in Central Nervous System

TypeobservationalSponsorIRCCS San RaffaeleRan2020 to 2023Enrolled300ConditionsCOVID-19 Testing, CNS Disease, CNS InfectionArmsDetermination of SARS-CoV2 presence in CNS
NCT04853836 phase4completednot on this map

Olfactory Disfunction After COVID-19: Conventional Therapy Versus Intervention Treatment With Co-ultraPEALut

TypeinterventionalSponsorUniversity Of PerugiaRan2020 to 2022Enrolled200ConditionsAnosmia, Covid19, Hyposmia, ParosmiaArmsco-ultraPEALut, Olfactory Rehab, PEA-LUT 1 sachet, PEA-LUT 2 sachet day
NCT04861402 completednot on this map

Non-Invasive Intracranial Pressure in COVID-19 Individuals

TypeobservationalSponsorFederal University of São PauloRan2020 to 2021Enrolled60ConditionsIntracranial PressureArmsThe ICP monitoring will be performed in a non-invasive method developed by Brain4Care
3 · Its place in the literature

Who cites it

556 citing papers in PubMed, 5 syntheses or guidelines pooled it, 1,005 citations in OpenAlex.

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  9. Neurodegenerative and Cognitive Consequences of Long COVID.International journal of molecular sciences · 2026
    Review
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496 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alberto Paniz-MondolfiDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.ORCID http://orcid.org/0000-0003-1259-1736
Clare BryceDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.
Zachary GrimesDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.
Ronald E GordonDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.
Jason ReidyDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.
John LednickyDepartment of Environmental and Global Health, College of Public Health and Health Professions, Emerging Pathogens Institute, University of Florida, Gainesville, Florida.
Emilia Mia SordilloDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.ORCID http://orcid.org/0000-0001-7787-3051
Mary FowkesDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York City, New York.
Icahn School of Medicine at Mount Sinai · USUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurologic sequelae can be devastating complications of respiratory viral infections. We report the presence of virus in neural and capillary endothelial cells in frontal lobe tissue obtained at postmortem examination from a patient infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Our observations of virus in neural tissue, in conjunction with clinical correlates of worsening neurologic symptoms, pave the way to a closer understanding of the pathogenic mechanisms underlying central nervous system involvement by SARS-CoV-2.

Indexed as

AgedAgeusiaAtaxiaBetacoronavirusClinical Laboratory TechniquesCoronavirus InfectionsCOVID-19COVID-19 TestingEndothelial CellsFatal OutcomeFrontal LobeHospitalizationHumansLungMaleNeuronsRNA, ViralCNS infectionendotheliumneuroinvasionneurotropismSARS-CoV-2

Identifiers

PMID32314810
PMCPMC7264598
OpenAlexW3016911319

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.