Evidence map›Paper›PMID 32314783›Full record

ArticleBioscience reports2020

VCAM-1-targeted and PPARδ-agonist-loaded nanomicelles enhanced suppressing effects on apoptosis and migration of oxidized low-density lipoprotein-induced vascular smooth muscle cells.

Gang Wei, Liangang Hao, Xueli Li, Wen Xu, Fuxiang Liu, Qian Peng, Shoutian Lv

RetractedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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  5. Cornelian Cherry (International journal of molecular sciences · 2023
    Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gang WeiDepartment of Vascular Surgery, Dongying People's Hospital, 317 Nanyi Road, Dongying District, Dongying City 257091, Shandong Province, China.
Liangang HaoDepartment of Vascular Surgery, Dongying People's Hospital, 317 Nanyi Road, Dongying District, Dongying City 257091, Shandong Province, China.
Xueli LiDepartment of Vascular Surgery, Dongying People's Hospital, 317 Nanyi Road, Dongying District, Dongying City 257091, Shandong Province, China.
Wen XuDepartment of Vascular Surgery, Dongying People's Hospital, 317 Nanyi Road, Dongying District, Dongying City 257091, Shandong Province, China.
Fuxiang LiuDepartment of Vascular Surgery, Dongying People's Hospital, 317 Nanyi Road, Dongying District, Dongying City 257091, Shandong Province, China.
Qian PengDepartment of Vascular Surgery, Dongying People's Hospital, 317 Nanyi Road, Dongying District, Dongying City 257091, Shandong Province, China.
Shoutian LvDepartment of Vascular Surgery, Dongying People's Hospital, 317 Nanyi Road, Dongying District, Dongying City 257091, Shandong Province, China.
Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNanomicelles (NMs) have been widely used for various biomedical applications due to its unique physiochemical properties. The present study aims to investigate the effects of vascular cell adhesion molecule-1 (VCAM-1)-targeted and peroxisome proliferator-activated receptor δ (PPARδ) agonist (GW0742)-loaded NMs on apoptosis and migration in oxidized low-density lipoprotein (ox-LDL)-induced human aortic vascular smooth muscle cells (HAVSMCs).

methodsThe GW0742-loaded NMs (M-GW) and VCAM-1-targeted NMs loaded with GW0742 (TM-GW) were prepared, and then the morphologies and the size distribution of M-GM and TM-GM were observed by transmission electron microscopy (TEM) and dynamic light scattering (DLS), respectively. In vitro drug release assay of M-GM and TM-GM were performed as well. Next, HAVSMCs were cultured in medium containing ox-LDL to mimic atherosclerotic environment, and the effects of free GW0742, M-GM and TM-GM on endocytosis, cell migration and apoptosis, as well as the expression of VCAM-1, and proteins associated with migration and apoptosis were measured in HAVSMCs treated with ox-LDL.

resultsM-GM and TM-GM were successfully prepared. VCAM-1 was overexpressed in HAVSMCs treated with ox-LDL, and TM-GM had a strong targeting ability to HAVSMCs treated with ox-LDL compared with M-GM. In addition, compared with free GW0742, both M-GM and TM-GM significantly diminished cell apoptosis and migration in HAVSMCs treated with ox-LDL.

conclusionsTM-GM had a superior suppressing effect on apoptosis and migration of ox-LDL-induced HAVSMCs.

Indexed as

Drug CarriersNanoparticlesApoptosisCell MovementCells, CulturedDrug CompoundingDrug LiberationHumansLipoproteins, LDLMicellesMuscle, Smooth, VascularMyocytes, Smooth MusclePhenolsPPAR gammaSignal TransductionSulfhydryl Compounds(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acidDrug CarriersLipoproteins, LDLMicellesoxidized low density lipoproteinPhenolsPPAR gammaPPARG protein, humanSulfhydryl CompoundsThiazolesVascular Cell Adhesion Molecule-1AtherosclerosisNano micellesPeroxisome proliferator-activated receptor δVascular cell adhesion molecule-1Vascular smooth muscle cell

Identifiers

PMID32314783
PMCPMC7218220
OpenAlexW3017011126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.