Evidence map›Paper›PMID 32314732›Full record

ArticleeLife2020

Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology.

John Kerwin, Israr Khan, Reproducibility Project: Cancer Biology

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Cancers · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. PTENP1 is a ceRNA for PTEN: it's CRISPR clear.Journal of hematology & oncology · 2020
    Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

John KerwinUniversity of Maryland, College Park, United States.
Israr KhanAlamo Laboratories Inc, San Antonio, United States.
Reproducibility Project: Cancer BiologyScience Exchange, Palo Alto, United States.
Center for Open Science · USScience Exchange (United States) · USUniversity of Maryland, College Park · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As part of the Reproducibility Project: Cancer Biology we published a Registered Report (Khan et al., 2015), that described how we intended to replicate selected experiments from the paper "A coding-independent function of gene and pseudogene mRNAs regulates tumour biology" (Poliseno et al., 2010). Here we report the results. We found

Indexed as

Cell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMaleProstatic NeoplasmsPseudogenesPTEN PhosphohydrolaseRNA, MessengerPTEN PhosphohydrolasePTEN protein, humanRNA, Messengercancer biologyhumanmetascienceNoncoding RNApseudogenePTENreplicationreproducibility

Identifiers

PMID32314732
PMCPMC7185998
OpenAlexW3017360055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.