Evidence map›Paper›PMID 32314730›Full record

ArticleeLife2020

Centering and symmetry breaking in confined contracting actomyosin networks.

Niv Ierushalmi, Maya Malik-Garbi, Angelika Manhart, Enas Abu Shah, Bruce L Goode, Alex Mogilner, Kinneret Keren

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Filament transport supports contractile steady states of actin networks.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Cytoplasmic stirring by active carpets.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Article
  8. Article
  9. Size- and position-dependent cytoplasm viscoelasticity through hydrodynamic interactions with the cell surface.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Geometric trade-off between contractile force and viscous drag determines the actomyosin-based motility of a cell-sized droplet.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. Contribution of cytoplasm viscoelastic properties to mitotic spindle positioning.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Cytoskeleton Force Exertion in Bulk Cytoplasm.Frontiers in cell and developmental biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Niv IerushalmiDepartment of Physics, Technion- Israel Institute of Technology, Haifa, Israel.
Maya Malik-GarbiDepartment of Physics, Technion- Israel Institute of Technology, Haifa, Israel.
Angelika ManhartDepartment of Mathematics, University College London, London, United Kingdom.
Enas Abu ShahDepartment of Physics, Technion- Israel Institute of Technology, Haifa, Israel.ORCID 0000-0001-5033-8171
Bruce L GoodeDepartment of Biology, Brandeis University, Waltham, United States.ORCID 0000-0002-6443-5893
Alex MogilnerCourant Institute of Mathematical Sciences and Department of Biology, New York University, New York, United States.ORCID 0000-0002-9310-3812
Kinneret KerenDepartment of Physics, Technion- Israel Institute of Technology, Haifa, Israel.ORCID 0000-0002-2962-6977
Technion – Israel Institute of Technology · ILBrandeis University · USCourant Institute of Mathematical Sciences · USUniversity College London · GB

Funding

MECHNISMS REGULATING ACTIN ASSEMBLYR01GM063691 · NIGMS · BRANDEIS UNIVERSITY · PI GOODE, BRUCE L · 2002 to 2019
$7.5M
Molecular and cellular mechanisms regulating actin dynamicsR35GM134895 · NIGMS · BRANDEIS UNIVERSITY · PI Bruce L Goode · 2020 to 2026
$7.3M
Sizing and Scaling in Functional Muscle CellsR01GM121971 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI BAYLIES, MARY K · 2017 to 2020
$1.8M
Army Research Office W911NF-17-1-0417Israel Science Foundation 957/15National Science Foundation MRSEC DMR-1420382NIGMS NIH HHS R01 GM063691NIGMS NIH HHS R01 GM121971NIGMS NIH HHS R35 GM134895NIH HHS GM121971United States-Israel Binational Science Foundation 2013275United States-Israel Binational Science Foundation 2017158
6 · The paper itself

Abstract

Centering and decentering of cellular components is essential for internal organization of cells and their ability to perform basic cellular functions such as division and motility. How cells achieve proper localization of their organelles is still not well-understood, especially in large cells such as oocytes. Here, we study actin-based positioning mechanisms in artificial cells with persistently contracting actomyosin networks, generated by encapsulating cytoplasmic

Indexed as

Actin CytoskeletonActomyosinAnimalsCell PolarityFemaleOocytesXenopusActomyosinactomyosin contractionartificial cellcell biologycenteringphysics of living systemssubcellular localizationsymmetry breakingxenopus

Identifiers

PMID32314730
PMCPMC7173961
OpenAlexW2964000869

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.