ArticleACS sensors2020
A Fluorescence and Surface-Enhanced Raman Spectroscopic Dual-Modal Aptasensor for Sensitive Detection of Cyanotoxins.
Article in ACS sensors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 113 citations in OpenAlex.
- Multiclass Cyanotoxins in Aquatic Environments: Occurrence, Impacts and Detection Techniques.Toxins · 2026Review
- Review
- In-situ growth of heterogeneous Au on MoSScientific reports · 2026Article
- Dual-Check CRISPR-SERS strategy for sensitively detecting Monkeypox DNA and its single-base mutated DNA.Mikrochimica acta · 2025Article
- Dual DNA recycling amplification-assisted CRISPR/Cas12a cleavage for dual-channel ratiometric fluorescence biosensing of kanamycin antibiotic.Analytical and bioanalytical chemistry · 2025Article
- Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges.ACS applied materials & interfaces · 2025Review
- Fluorescent/colorimetric dual-mode for detecting of MC-LR using bidirectional RCA coupled with CdTe QDs.Mikrochimica acta · 2025Article
- Advances in Aptamer-Based Biosensors for the Detection of Foodborne Mycotoxins.Molecules (Basel, Switzerland) · 2024Review
- Ultrasensitive Ochratoxin A Detection in Cereal Products Using a Fluorescent Aptasensor Based on RecJFoods (Basel, Switzerland) · 2024Article
- Fast cathodic electrodeposition of ZnTCPP-functionalized metal-organic framework films for preparation of a fluorescent aptamer sensor for microcystin determination.Mikrochimica acta · 2023Article
- SERS-fluorescence dual-mode nanoprobe for the detection and imaging of Bax mRNA during apoptosis.Mikrochimica acta · 2023Article
- Nucleotide detection mechanism and comparison based on low-dimensional materials: A review.Frontiers in bioengineering and biotechnology · 2023Review
- Detection and Characterization of Nodularin by Using Label-Free Surface-Enhanced Spectroscopic Techniques.International journal of molecular sciences · 2022Article
- A review of spectroscopic probes constructed from aptamer-binding gold/silver nanoparticles or their dimers in environmental pollutants' detection.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2022Review
- Portable, multi-modal Raman and fluorescence spectroscopic platform for point-of-care applications.Journal of biomedical optics · 2022Article
- Combating small molecule environmental contaminants: detection and sequestration using functional nucleic acids.Chemical science · 2022Review
- Magnetically Enhanced Liquid SERS for Ultrasensitive Analysis of Bacterial and SARS-CoV-2 Biomarkers.Frontiers in bioengineering and biotechnology · 2021Article
- Selectively enhanced Raman/fluorescence spectra in photonic-plasmonic hybrid structures.Nanoscale advances · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The ability to detect trace analytes without necessitating solid surface attachment or complicated processing steps would facilitate the translation of sensors for monitoring environmental toxins in the field. To address a critical unmet need in fresh water ecology, we have developed a dual-modal aptamer-based biosensor (aptasensor), featuring fluorescence and surface-enhanced Raman spectroscopy (SERS), for sensitive and selective detection of hepatotoxin microcystin-LR (MC-LR). The rational sensor design is based on the high affinity of the cyanine (Cy3) dye-modified complementary DNA (Cy3-cDNA) strand toward the plasmonic gold nanostars (GNSs) in comparison to the Cy3-cDNA/aptamer duplex. The preferential binding of MC-LR toward the MC-LR-specific aptamer triggers the dissociation of Cy3-cDNA/aptamer duplexes, which switches the Cy3's fluorescence "off" and SERS "on" due to the proximity of Cy3 dye to the GNS surface. Both fluorescence and SERS intensities are observed to vary linearly with the MC-LR concentration over the range of investigation. We have achieved high sensitivity and excellent specificity with the aptasensor toward MC-LR, which can be attributed to the fluorescence quenching effect, significant SERS enhancement by the GNSs, and the high affinity of the aptamer toward the MC-LR analytes. We further demonstrate the applicability of the present aptasensor for detection of MC-LR in a diverse set of real water samples with high accuracy and excellent reproducibility. With further refinement, we believe that the aptamer-driven complementary assembly of the SERS and fluorescence sensing constructs can be applied for rapid, multiplexed, and robust measurements of environmental toxins in the field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.