ArticleCancer medicine2020
CircSMC3 regulates gastric cancer tumorigenesis by targeting miR-4720-3p/TJP1 axis.
Article in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Comprehensive profiling of circRNAs reveals stimulus-specific networks and core regulators of cellular senescence.PloS one · 2026Article
- The role of circular RNAs in gastric Cancer: Focusing on autophagy, EMT, and their crosstalk.Biochemistry and biophysics reports · 2025Review
- Novel roles of LSECtin in gastric cancer cell adhesion, migration, invasion, and lymphatic metastasis.Cell death & disease · 2022Article
- Gastric Cancer Pre-Stage Detection and Early Diagnosis of Gastritis Using Serum Protein Signatures.Molecules (Basel, Switzerland) · 2022Article
- Role of zonula occludens in gastrointestinal and liver cancers.World journal of clinical cases · 2022Review
- Plasma Exosomal CircNEK9 Accelerates the Progression of Gastric Cancer via miR-409-3p/MAP7 Axis.Digestive diseases and sciences · 2021Article
- The microarray identification circular RNA hsa_circ_0105015 up-regulated involving inflammation pathway in essential hypertension.Journal of clinical laboratory analysis · 2021Article
- CircCDYL Acts as a Tumor Suppressor in Wilms' Tumor by Targeting miR-145-5p.Frontiers in cell and developmental biology · 2021Article
- Circular RNAs in gastrointestinal cancer: Current knowledge, biomarkers and targeted therapy (Review).International journal of molecular medicine · 2020Review
- Hsa_circRNA_0000518 facilitates breast cancer development via regulation of the miR-326/FGFR1 axis.Thoracic cancer · 2020Article
- CircSMC3 regulates gastric cancer tumorigenesis by targeting miR-4720-3p/TJP1 axis.Cancer medicine · 2020Article
- Circ_0062020 Knockdown Strengthens the Radiosensitivity of Prostate Cancer Cells.Cancer management and research · 2020Article
- Comprehensive Analysis of Differentially Expressed circRNAs Reveals a Colorectal Cancer-Related ceRNA Network.Computational and mathematical methods in medicine · 2020Article
- Macrophage-derived exosomes regulate gastric cancer cell oxaliplatin resistance by wrapping circ 0008253.Cell cycle (Georgetown, Tex.)Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circular RNAs (circRNAs) are identified to play an evident role in many human cancers, such as gastric cancer. However, the potential mechanisms underlying the circRNA-induced pathogenesis in gastric cancers are still elusive. The present study is designed to unfold the mechanism by which circRNAs involve in gastric cancer progression. Using circRNAs microarray, we detected the dysregulated circRNAs and identified an upregulated circRNA, circSMC3 (hsa_circ_0000260), in gastric cancer tissues. Patients with high circSMC3 expression levels had a poor overall survival via Kaplan-Meier survival analysis implied that gastric cancer. Functionally, loss of circSMC3 abolished the proliferation and motility of gastric cancer cells. Mechanically, circSMC3 decreased miR-4720-3p expression by acting as a miRNA sponge, and tight junction protein 1 (TJP1) 3'UTR was identified to be the target of miR-4720-3p, contributing to a circSMC3/miR-4720-3p/TJP1 axis. Thus, our results indicate that circSMC3 promotes gastric cancer cell proliferation and motility through miR-4720-3p/TJP1.
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