ArticleDiabetes, obesity & metabolism2020
Hyperglucosuria induced by dapagliflozin augments bacterial colonization in the murine urinary tract.
Article in Diabetes, obesity & metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Systematic Review of Literature Examining Bacterial Urinary Tract Infections in Diabetes.Journal of diabetes research · 2022Pooled it
- Diabetes Mellitus Affects Urinary Tissue Tropism of Group B Streptococci in a Sex-Dependent Manner.Pathogens (Basel, Switzerland) · 2026Article
- Diabetes and hyperglucosuria exacerbate the severity of urinary tract infection caused by uropathogenicInfection and immunity · 2026Article
- Selective sugar transport supports Proteus mirabilis fitness in the urinary tract.PLoS pathogens · 2026Article
- Beyond bacteremia: clinical phenotypes and determinants of mortality in hospitalized adults with community-acquired urinary tract infection.Frontiers in medicine · 2026Article
- Analysing the influence of dapagliflozin on urinary tract infection vulnerability and kidney injury in mice infected with uropathogenic Escherichia coli.Diabetes, obesity & metabolism · 2025Article
- Article
- Animal models ofFrontiers in microbiology · 2024Review
- Vaginal Inoculation of Uropathogenic Escherichia coli during Estrus Leads to Genital and Renal Colonization.Infection and immunity · 2022Article
- The immune responses to differentFrontiers in immunology · 2022Review
- Article
- The influence of intermittent hypoxia, obesity, and diabetes on male genitourinary anatomy and voiding physiology.American journal of physiology. Renal physiology · 2021Article
- Sodium-glucose co-transporter 2 inhibitors use and the risks of genital and urinary tract infection: What should we know?Tzu chi medical journalReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
aimTo test the effects of dapagliflozin-induced hyperglucosuria on ascending bacterial urinary tract infection (UTI) in a mouse model.
methodsDapagliflozin or canagliflozin was used to induce hyperglucosuria in non-diabetic adult female mice prior to transurethral inoculation with uropathogenic Escherichia coli (UPEC) or Klebsiella pneumoniae. Glucose, bacterial load, cytokines, neutrophil mobilization and inflammation during acute and chronic UTI were determined.
resultsSignificant increase in UPEC load was observed in the urinary tract of hyperglucosuric mice compared with controls. Dapagliflozin-treated mice developed bacteraemia resulting in UPEC colonization of the spleen and liver at a higher frequency than controls. Chronic UTI in hyperglucosuric mice resulted in an increased incidence of renal abscesses. Histopathological evaluation revealed only modest increases in tissue damage in the urinary bladders and kidneys of dapagliflozin-treated mice, despite a profound increase in bacterial load. There was poor neutrophil mobilization to the urine of hyperglucosuric mice. We also observed a delayed increase of IL-1β in urine, and bladders, and IL-6 in urine of hyperglucosuric mice. Experimental inoculation with K. pneumoniae also revealed higher bacterial burden in the urinary bladder, spleen and liver from dapagliflozin-treated mice compared with controls.
conclusionCollectively, our results indicate that dapagliflozin-induced hyperglucosuria in non-diabetic female mice leads to increased susceptibility to severe UTI, and bacteraemia of urinary tract origin.
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