ArticlePediatric diabetes2020
Association between prediabetes diagnosis and body mass index trajectory of overweight and obese adolescents.
Article in Pediatric diabetes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Recorded diagnosis of overweight/obesity in primary care is linked to obesity care performance rates.Pediatric research · 2025Article
- Prediabetes in children and adolescents: An updated review.World journal of clinical pediatrics · 2023Review
- Perception and Awareness of Diabetes Risk and Reported Risk-Reducing Behaviors in Adolescents.JAMA network open · 2023Article
- Which Is the Most Appropriate Cut-Off of HbA1c for Prediabetes Screening in Caucasian Youths with Overweight or Obesity?International journal of environmental research and public health · 2023Article
- Phenotypes of prediabetes and metabolic risk in Caucasian youths with overweight or obesity.Journal of endocrinological investigation · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundPrediabetes awareness in adults has been associated with improved weight management. Whether youth with prediabetes diagnosis experience similar improvements is unknown.
objectiveTo investigate the association between prediabetes identification and body mass index (BMI) trajectory in overweight and obese adolescents. SUBJECTS: Youth who were followed longitudinally in a large academic-affiliated primary care network and who were overweight/obese while 10 to 18 years old.
methodsRetrospective cohort study. Subjects were categorized as "screened" if at least 1 hemoglobin A1c (HbA1c) result was available. Time series analysis was used to determine the difference in difference (DID) in BMI Z-score (BMI-Z) slope before and after HbA1c between: (a) screened youth found to have prediabetes-range HbA1c (5.7%-6.4%, 39-46 mmol/mol) versus normal HbA1c and (b) screened versus age-matched unscreened obese youth.
resultsA total of 4184 (55.6% female) screened subjects (median follow-up 9.7 years) were included. In which, 637 (15.2%) had prediabetes-range HbA1c. Prediabetes was associated with a greater decrease in BMI-Z slope than normal HbA1c (DID: -0.023/year [95% CI: -0.042 to -0.004]). When compared to age-matched unscreened subjects (n = 2087), screened subjects (n = 2815) experienced a greater decrease in BMI-Z slope after HbA1c than unscreened subjects at a matched age (DID: -0.031/y [95% CI -0.042 to -0.021]).
conclusionsBMI-Z trajectory improved more among youth with prediabetes-range HbA1c but also stabilized in screened youth overall. Prospective studies are needed to identify provider- and patient-level drivers of this observation.
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