Evidence map›Paper›PMID 32314454›Full record

ArticleCancer science2020

Tyrosine kinase inhibitors induce alternative spliced BCR-ABL

Junichiro Yuda, Jun Odawara, Mariko Minami, Tsuyoshi Muta, Kentaro Kohno, Kazuki Tanimoto, Tetsuya Eto, Takahiro Shima, Yoshikane Kikushige, Koji Kato and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Junichiro YudaDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.ORCID https://orcid.org/0000-0002-4908-1636
Jun OdawaraDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Mariko MinamiDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Tsuyoshi MutaDepartment of Hematology and Oncology, Japan Community Health Care Organization Kyushu Hospital, Fukuoka, Japan.
Kentaro KohnoDepartment of Hematology and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Kazuki TanimotoDepartment of Haematology and Oncology, Japanese Red Cross Society Fukuoka Red Cross Hospital, Fukuoka, Japan.
Tetsuya EtoDepartment of Hematology, Hamanomachi Hospital, Fukuoka, Japan.
Takahiro ShimaDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Yoshikane KikushigeDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Koji KatoDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Katsuto TakenakaDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Hiromi IwasakiDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Yosuke MinamiDepartment of Hematology, National Cancer Center Hospital East, Kashiwa, Japan.
Yasuyuki OhkawaDepartment of Advanced Medical Initiatives, Kyushu University, Fukuoka, Japan.
Koichi AkashiDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.
Toshihiro MiyamotoDepartment of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan.ORCID https://orcid.org/0000-0002-6533-1594
Kyushu University · JPHamanomachi Hospital · JPJapanese Red Cross Fukuoka Hospital · JPKyushu Hospital · JPNational Cancer Center Hospital East · JPNational Kyushu Medical Center · JP

Funding

Bristol-Myers SquibbGrant-in-Aid for Scientific Research 16H05340Grant in Aid for Scientific Research on Innovative Areas "Stem Cell Aging and Disease"Ministry of Education, Culture, Sports, Science and Technology of Japan 25115002
6 · The paper itself

Abstract

To elucidate dynamic changes in native BCR-ABL and alternatively spliced tyrosine kinase inhibitor (TKI)-resistant but function-dead BCR-ABL

Indexed as

Alternative SplicingMutationAdultAgedFemaleFusion Proteins, bcr-ablGene Expression Regulation, LeukemicGenetic LociHigh-Throughput Nucleotide SequencingHumansIntronsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMaleMiddle AgedProtein Kinase InhibitorsRNA Polymerase IIFusion Proteins, bcr-ablProtein Kinase InhibitorsRNA Polymerase IIalternative splicingBCR-ABLBCR-ABLIns35bpchronic myeloid leukemiaMRD

Identifiers

PMID32314454
PMCPMC7385367
OpenAlexW3016824625

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.