Evidence map›Paper›PMID 32314315›Full record

ArticlePharmacoEconomics2020

Valuing the AD-5D Dementia Utility Instrument: An Estimation of a General Population Tariff.

Tracy A Comans, Kim-Huong Nguyen, Julie Ratcliffe, Donna Rowen, Brendan Mulhern

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in PharmacoEconomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  5. Review
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  8. Developing an Australian utility value set for the Early Childhood Oral Health Impact Scale-4D (ECOHIS-4D) using a discrete choice experiment.The European journal of health economics : HEPAC : health economics in prevention and care · 2023
    Article
  9. Developing an Australian utility value set for MacNew-7D health states.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Tracy A ComansThe Centre for Health Services Research, University of Queensland, St. Lucia, Brisbane, QLD, Australia. t.comans@uq.edu.au.ORCID http://orcid.org/0000-0003-2840-3496
Kim-Huong NguyenThe Centre for Health Services Research, University of Queensland, St. Lucia, Brisbane, QLD, Australia.
Julie RatcliffeCaring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, SA, Australia.
Donna RowenHealth Economics and Decision Science, School of Health and Related Research, University of Sheffield, Sheffield, UK.
Brendan MulhernCentre for Health Economics Research and Evaluation, University of Technology Sydney, Sydney, NSW, Australia.
The University of Queensland · AUFlinders University · AUUniversity of Sheffield · GBUniversity of Technology Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis paper reports on the valuation of quality-of-life states in the Alzheimer's Disease Five Dimensions (AD-5D) instrument in a representative sample of the general population in Australia using the discrete-choice experiment with duration (DCE

methodA DCE with 200 choice sets of two quality-of-life (QoL) state-duration combinations blocked into 20 survey versions, with ten choice sets in each version, was designed and administered online to a sample representative of the Australian population. Two additional choice sets comprising internal consistency and dominance checks were included in each survey version. A range of model specifications investigating preferences with respect to duration and interactions between AD-5D dimension levels were estimated. Utility weights were developed, with estimated coefficients transformed to the 0 (being dead) to 1 (full health) scale, suitable for the calculation of quality-adjusted life-year (QALY) weights for use in economic evaluation.

resultsIn total, 1999 respondents completed the choice experiment. Overall, respondents were slightly better educated and had higher annual incomes than the Australian general population. The estimation results from different specifications and models were broadly consistent with the monotonic nature of the AD-5D: utility increased with increased life expectancy and decreased as the severity level for each dimension worsened. A utility value set was generated for the calculation of utilities for all QoL states defined by the AD-5D descriptive system.

conclusionThe DCE-based utility value set is now available to use to generate QALYs for the economic evaluation of treatments and interventions targeting people with dementia and/or their family caregivers.

Indexed as

Models, TheoreticalQuality-Adjusted Life YearsQuality of LifeAdultAgedAlzheimer DiseaseAustraliaCaregiversChoice BehaviorCost-Benefit AnalysisDementiaFemaleHumansLife ExpectancyMaleMiddle Aged

Identifiers

PMID32314315
OpenAlexW3017335292

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.