ArticleInfection2020
Metagenomic next-generation sequencing in the diagnosis of severe pneumonias caused by Chlamydia psittaci.
Article in Infection, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 1 of them a synthesis that pooled it.
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Who cites it
95 citing papers in PubMed, 1 synthesis or guideline pooled it, 139 citations in OpenAlex.
- The Effectiveness of Metagenomic Next-Generation Sequencing in the Diagnosis of Prosthetic Joint Infection: A Systematic Review and Meta-Analysis.Frontiers in cellular and infection microbiology · 2022Pooled it
- Current status and challenges in the diagnosis and treatment of psittacosis.Infectious diseases & immunity · 2026Review
- Clinical characteristics of Chlamydia psittaci pneumonia diagnosed by next-generation sequencing: An observational study.Medicine · 2026Observational
- Application of BALF combined with tNGS for detecting Chlamydia psittaci in resource-limited areas: lessons learned from the 2025 temporally associated case series investigation.BMC infectious diseases · 2026Article
- Observational
- Clinical Features and Risk Factors for Severe Disease in 57 Cases ofInfection and drug resistance · 2026Article
- Clinical Characteristics and Machine Learning-Based Severity Classification ofInfection and drug resistance · 2026Article
- Case Report: Coinfection ofFrontiers in medicine · 2026Article
- Early diagnosis and therapy of Chlamydia psittaci pneumonia: insights from chest CT, tNGS, and omadacycline in 34 cases.Frontiers in medicine · 2026Article
- Pathogen-targeted quick multiplex PCR identification ofFrontiers in medicine · 2026Article
- Non-invasive management of severe chlamydia psittaci pneumonia presenting with hypoxemia and diarrhea: a case report.Frontiers in medicine · 2026Article
- Clinical Characteristics of 40 Cases ofInfection and drug resistance · 2026Article
- A case of severe psittacosis in a hemodialysis patient-the critical role of detailed medical history and next-generation sequencing.Frontiers in medicine · 2026Article
- Online parrot trade as a source of psittacosis caused by a novelFrontiers in microbiology · 2026Article
- Article
- Clinical utility of metagenomic next-generation sequencing (mNGS) and a novel PCR-based point-of-care testing (POCT) for pathogen detection in pulmonary infections: a retrospective study.BMC infectious diseases · 2025Article
- Clinical characteristics and risk factors associated with severe community-acquired pneumonia infected byMicrobiology spectrum · 2025Article
- A case-control study onFrontiers in medicine · 2025Article
- Analysis of Clinical Characteristics and Severe Factors of 47 Cases of Psittacosis.Infection and drug resistance · 2025Article
- Clinical characteristics ofFrontiers in medicine · 2025Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
purposeChlamydia psittaci infection in humans can lead to serious clinical manifestations, including severe pneumonia, adult respiratory distress syndrome, and, rarely, death. Implementation of metagenomic next-generation sequencing (mNGS) gives a promising new tool for diagnosis. The clinical spectrum of severe psittacosis pneumonia is described to provide physicians with a better understanding and to highlight the rarity and severity of severe psittacosis pneumonia.
methodsNine cases of severe psittacosis pneumonia were diagnosed using mNGS. Retrospective analysis of the data on disease progression, new diagnosis tool, treatments, and outcomes, and the findings were summarised.
resultsFrequent symptoms included chills and remittent fever (100%), cough and hypodynamia (100%), and headache and myalgia (77.8%). All patients were severe psittacosis pneumonia developed respiratory failure, accompanied by sepsis in 6/9 patients. mNGS takes 48-72 h to provide the results, and help to identify diagnosis of psittacosis. Laboratory data showed normal or slightly increased leucocytes, neutrophils, and procalcitonin but high C-reactive protein levels. Computed tomography revealed air-space consolidation and ground-glass opacity, which began in the upper lobe of one lung, and spread to both lungs, along with miliary, nodular, or consolidated shadows. One patient died because of secondary infection with Klebsiella pneumoniae, while the other eight patients experienced complete recoveries.
conclusionsThe use of mNGS can improve accuracy and reduce the delay in diagnosis of psittacosis. Severe psittacosis pneumonia responds well to the timely use of appropriate antibiotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.