Evidence map›Paper›PMID 32314301›Full record

ArticleAnnals of biomedical engineering2020

Enzyme-Mediated Conjugation of Peptides to Silk Fibroin for Facile Hydrogel Functionalization.

Meghan McGill, James M Grant, David L Kaplan

Open access · greenAbstract read
In one paragraph

Article in Annals of biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
  2. Engineered Tissue Models to Decode Host-Microbiota Interactions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  3. Article
  4. Silk fibroin-based inks forBioactive materials · 2024
    Article
  5. Silk Bioconjugates: From Chemistry and Concept to Application.ACS biomaterials science & engineering · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Silk chemistry and biomedical material designs.Nature reviews. Chemistry · 2023
    Review
  11. Bioinks adapted forRSC advances · 2023
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Meghan McGillDepartment of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA, 02155, USA.
James M GrantDepartment of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA, 02155, USA.
David L KaplanDepartment of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA, 02155, USA. david.kaplan@tufts.edu.ORCID http://orcid.org/0000-0002-9245-7774
Tufts University · US

Funding

Tissue Engineering Resource Center: TTDP41EB027062 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gordana Vunjak-Novakovic · 2019 to 2026
$12.6M
Models to Predict Protein Biomaterial PerformanceU01EB014976 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI BUEHLER, MARKUS J., KAPLAN, DAVID L. · 2012 to 2020
$5.2M
Building a Research Analytic Initiative at NARI-India (BRAIN-I)D71TW010333 · FIC · NATIONAL AIDS RESEARCH INSTITUTE · PI SAHAY, SEEMA · 2016 to 2017
$60k
Air Force Office of Scientific Research FA9550-17-1-0333NIBIB NIH HHS P41 EB027062NIBIB NIH HHS U01 EB014976NIH HHS P41EB027062
6 · The paper itself

Abstract

Enzymatic crosslinking of tyrosine is a simple and modular method for adding functional peptides to silk fibroin (SF) hydrogels. Silk fibroin is a naturally derived polymer notable for its robust mechanical properties, biological compatibility, and versatility. Hydrogels fabricated from SF are elastic, optically clear, and have tunable moduli, however, they do not contain native biological epitopes for cell interactions. In this work we demonstrate the attachment of peptides to SF hydrogels through crosslinking of tyrosine with horseradish peroxidase (HRP) and hydrogen peroxide (H

Indexed as

Biocompatible MaterialsCell ProliferationCells, CulturedFibroblastsFibroinsHorseradish PeroxidaseHumansHydrogelsHydrogen PeroxideOligopeptidesTyrosinearginyl-glycyl-aspartic acidBiocompatible MaterialsFibroinsHorseradish PeroxidaseHydrogelsHydrogen PeroxideOligopeptidesTyrosineBiopolymersEnzymatic reactionFunctionalizationHorseradish peroxidase (HRP)HydrogelPeptideSilk fibroin

Identifiers

PMID32314301
PMCPMC7334058
OpenAlexW3016304314

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.