ArticleBrain imaging and behavior2021
APOE ε4 and cognitive reserve effects on the functional network in the Alzheimer's disease spectrum.
Article in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Beneficial Effect of Societal Factors on APOE-ε2 and ε4 Carriers' Brain Health: A Systematic Review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Pooled it
- Cognitive resilience/reserve: Myth or reality? A review of definitions and measurement methods.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- The Alzheimer's Disease Neuroimaging Initiative in the era of Alzheimer's disease treatment: A review of ADNI studies from 2021 to 2022.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- A unique color-coded visualization system with multimodal information fusion and deep learning in a longitudinal study of Alzheimer's disease.Artificial intelligence in medicine · 2023Article
- Toward an Understanding of Healthy Cognitive Aging: The Importance of Lifestyle in Cognitive Reserve and the Scaffolding Theory of Aging and Cognition.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Review
- Local Brain Network Alterations and Olfactory Impairment in Alzheimer's Disease: An fMRI and Graph-Based Study.Brain sciences · 2023Article
- Review
- Treatment Enhances Betweenness Centrality of Fronto-Parietal Network in Parkinson's Patients.Frontiers in computational neuroscience · 2022Article
- Abnormal Dynamic Functional Networks in Subjective Cognitive Decline and Alzheimer's Disease.Frontiers in computational neuroscience · 2022Article
- Brain Entropy Mapping in Healthy Aging and Alzheimer's Disease.Frontiers in aging neuroscience · 2020Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
The apolipoprotein E (APOE) ε4 allele is a genetic risk factor for Alzheimer's disease, whereas educational attainments have protective effects against cognitive decline in aging and patients with Alzheimer's disease. We examined the possible effects of years of education and APOE genotype on the topological properties of the functional network in normal aging, mild cognitive impairment and Alzheimer's disease. The years of education showed a significant, negative association with the local efficiency, clustering coefficient and small-worldness of functional networks in APOE ε4 noncarriers but not in ε4 carriers. These associations were mainly observed in normal aging and were reduced in mild cognitive impairment and Alzheimer's disease. Moreover, regions of the inferior frontal gyrus, temporal pole, and cuneus also showed correlations between education and nodal degree. Our findings demonstrated that the protective effects of education persist in APOE ε4 noncarriers but diminish in ε4 carriers. In addition, the protective effects of education were attenuated or reduced in the progression of Alzheimer's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.