ArticleBrain imaging and behavior2021
Abnormalities in the thalamo-cortical network in patients with functional constipation.
Article in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Exploring brain activity differences in functional constipation using fNIRS: a case-control study.Journal of neuroengineering and rehabilitation · 2026Article
- Constipation Is Linked to Neuroinflammation in Early Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Task-Dependent Cortical Oscillatory Dynamics in Functional Constipation.Sensors (Basel, Switzerland) · 2025Article
- Abnormal connection between the posterior insula and the gastric network among patients with functional constipation.Frontiers in human neuroscience · 2025Article
- Abnormalities of white matter network properties in middle-aged and elderly patients with functional constipation.Frontiers in neurology · 2024Article
- Beyond nodes and edges: a bibliometric analysis on graph theory and neuroimaging modalities.Frontiers in neuroscience · 2024Review
- Gut Microbiome-Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders.ACS chemical neuroscience · 2023Review
- Altered intrinsic functional brain architecture in patients with functional constipation: a surface-based network study.Frontiers in neuroscience · 2023Article
- Alterations in functional connectivity and interactions in resting-state networks in female patients with functional constipation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Brain structural changes in regions within the salience network in patients with functional constipation.Brain imaging and behavior · 2022Article
- Intra and inter: Alterations in functional brain resting-state networks in patients with functional constipation.Frontiers in neuroscience · 2022Article
- Aberrant resting-state functional connectivity and topological properties of the subcortical network in functional dyspepsia patients.Frontiers in molecular neuroscience · 2022Article
- Neurophysiological Effects of the Anterior Cingulate Cortex on the Exacerbation of Crohn's Disease: A Combined fMRI-MRS Study.Frontiers in neuroscience · 2022Article
- Aberrant functional brain network dynamics in patients with functional constipation.Human brain mapping · 2021Article
- Changes in the anterior cingulate cortex in Crohn's disease: A neuroimaging perspective.Brain and behavior · 2021Review
- Transcriptomic Signatures Associated With Gray Matter Volume Changes in Patients With Functional Constipation.Frontiers in neuroscience · 2021Article
- Alterations of White Matter Network Properties in Patients With Functional Constipation.Frontiers in neurology · 2021Article
- Altered Functional Connectivity Within and Between Salience and Sensorimotor Networks in Patients With Functional Constipation.Frontiers in neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional constipation (FCon) is a common functional gastrointestinal disorder (FGID); neuroimaging studies have shown brain functional abnormalities in thalamo-cortical regions in patients with FGID. However, association between FCon and topological characteristics of brain networks remains largely unknown. We employed resting-state functional magnetic resonance imaging (RS-fMRI) and graph theory approach to investigate functional brain topological organization in 42 patients with FCon and 41 healthy controls (HC) from perspectives of global, regional and modular levels. Results showed patients with FCon had a significantly lower normalized clustering coefficient and small-worldness, implying decreased brain functional connectivity. Regions showed altered nodal degree and efficiency mainly located in the thalamus, rostral anterior cingulate cortex (rACC), and supplementary motor area (SMA), which are involved in somatic/sensory, emotional processing and motor-control. For the modular analysis, thalamus, rACC and SMA had an aberrant within-module nodal degree and nodal efficiency, and thalamus-related network exhibited abnormal interaction with the limbic network (amygdala and hippocampal gyrus). Nodal degree in the thalamus was negatively correlated with difficulty of defecation, and nodal degree in the rACC was negatively correlated with sensation of incomplete evacuation. These findings indicated that FCon was associated with abnormalities in the thalamo-cortical network.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.