Evidence map›Paper›PMID 32314107›Full record

ArticleCancer causes & control : CCC2020

Pesticide use and risk of Hodgkin lymphoma: results from the North American Pooled Project (NAPP).

Lidija Latifovic, Laura E Beane Freeman, John J Spinelli, Manisha Pahwa, Linda Kachuri, Aaron Blair, Kenneth P Cantor, Shelia Hoar Zahm, Dennis D Weisenburger, John R McLaughlin and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Exposure to pesticides and oxidative stress in Brazilian agricultural communities.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2021
    Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

Lidija LatifovicOccupational Cancer Research Centre, Cancer Care Ontario, Toronto, ON, Canada.
Laura E Beane FreemanDivision of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.
John J SpinelliPopulation Oncology, BC Centre, Vancouver, BC, Canada.
Manisha PahwaOccupational Cancer Research Centre, Cancer Care Ontario, Toronto, ON, Canada.
Linda KachuriOccupational Cancer Research Centre, Cancer Care Ontario, Toronto, ON, Canada.
Aaron BlairDivision of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.
Kenneth P CantorDivision of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.
Shelia Hoar ZahmShelia Zahm Consulting, Hermon, ME, USA.
Dennis D WeisenburgerDepartment of Pathology, City of Hope Medical Center, Duarte, CA, USA.
John R McLaughlinOccupational Cancer Research Centre, Cancer Care Ontario, Toronto, ON, Canada.
James A DosmanUniversity of Saskatchewan, Saskatoon, SK, Canada.
Punam PahwaUniversity of Saskatchewan, Saskatoon, SK, Canada.
Stella KoutrosDivision of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.
Paul A DemersOccupational Cancer Research Centre, Cancer Care Ontario, Toronto, ON, Canada.
Shelley A HarrisOccupational Cancer Research Centre, Cancer Care Ontario, Toronto, ON, Canada. shelley.harris@utoronto.ca.
National Cancer Institute · USOccupational Cancer Research Centre · CAUniversity of Saskatchewan · CAUniversity of Toronto · CACancer Care Ontario · CACity Of Hope National Medical Center · USUniversity of British Columbia · CAUniversity of California, San Francisco · US

Funding

Studies of Occupational Cancer (Pesticides)ZIACP010119 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI BEANE FREEMAN, LAURA · 2009 to 2025
$46.1M
Canadian Cancer Society 703055
6 · The paper itself

Abstract

purposeThe purpose of this study was to investigate associations between pesticide exposures and risk of Hodgkin lymphoma (HL) using data from the North American Pooled Project (NAPP).

methodsThree population-based studies conducted in Kansas, Nebraska, and six Canadian provinces (HL = 507, Controls = 3886) were pooled to estimate odds ratios and 95% confidence intervals for single (never/ever) and multiple (0, 1, 2-4, ≥ 5) pesticides used, duration (years) and, for select pesticides, frequency (days/year) using adjusted logistic regression models. An age-stratified analysis (≤ 40/ > 40 years) was conducted when numbers were sufficient.

resultsIn an analysis of 26 individual pesticides, ever use of terbufos was significantly associated with HL (OR: 2.53, 95% CI 1.04-6.17). In age-stratified analyses, associations were stronger among those ≤ 40 years of age. No significant associations were noted among those > 40 years old; however, HL cases ≤ 40 were three times more likely to report ever using dimethoate (OR: 3.76 95% CI 1.02-33.84) and almost twice as likely to have ever used malathion (OR: 1.86 95% CI 1.00-3.47). Those ≤ 40 years of age reporting use of 5 + organophosphate insecticides had triple the odds of HL (OR: 3.00 95% CI 1.28-7.03). Longer duration of use of 2,4-D, ≥ 6 vs. 0 years, was associated with elevated odds of HL (OR: 2.59 95% CI 1.34-4.97).

conclusionIn the NAPP, insecticide use may increase the risk of HL, but results are based on small numbers.

Indexed as

PesticidesAdultCanadaEnvironmental ExposureHodgkin DiseaseHumansKansasNebraskaPesticidesCancerCase–controlHodgkin lymphomaInsecticideOrganophosphatePesticide

Identifiers

PMID32314107
PMCPMC7183499
OpenAlexW3017192321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.