Evidence map›Paper›PMID 32314019›Full record

ArticleActa diabetologica2020

Association of co-accumulation of arsenic and organophosphate insecticides with diabetes and atherosclerosis in a rural agricultural community: KMCH-NNCD-I study.

Ganesan Velmurugan, Krishnan Swaminathan, Sundaresan Mohanraj, Mani Dhivakar, Ganesh Veerasekar, Thomas Alexander, Mathew Cherian, Nalla G Palaniswami, Thalappil Pradeep

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In one paragraph

Article in Acta diabetologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ganesan Velmurugan *DST Unit of Nanoscience and Thematic Unit of Excellence in Water Research, Department of Chemistry, Indian Institute of Technology, Chennai, Tamil Nadu, 600 036, India. vel@kmchrf.org.ORCID http://orcid.org/0000-0001-7536-4472
Krishnan Swaminathan *DST Unit of Nanoscience and Thematic Unit of Excellence in Water Research, Department of Chemistry, Indian Institute of Technology, Chennai, Tamil Nadu, 600 036, India.
Sundaresan MohanrajChemomicrobiomics Laboratory, KMCH Research Foundation, Kovai Medical Centre and Hospital, Coimbatore, Tamil Nadu, 641 014, India.
Mani DhivakarDST Unit of Nanoscience and Thematic Unit of Excellence in Water Research, Department of Chemistry, Indian Institute of Technology, Chennai, Tamil Nadu, 600 036, India.
Ganesh VeerasekarChemomicrobiomics Laboratory, KMCH Research Foundation, Kovai Medical Centre and Hospital, Coimbatore, Tamil Nadu, 641 014, India.
Thomas AlexanderChemomicrobiomics Laboratory, KMCH Research Foundation, Kovai Medical Centre and Hospital, Coimbatore, Tamil Nadu, 641 014, India.
Mathew CherianChemomicrobiomics Laboratory, KMCH Research Foundation, Kovai Medical Centre and Hospital, Coimbatore, Tamil Nadu, 641 014, India.
Nalla G PalaniswamiChemomicrobiomics Laboratory, KMCH Research Foundation, Kovai Medical Centre and Hospital, Coimbatore, Tamil Nadu, 641 014, India.
Thalappil PradeepDST Unit of Nanoscience and Thematic Unit of Excellence in Water Research, Department of Chemistry, Indian Institute of Technology, Chennai, Tamil Nadu, 600 036, India. pradeep@iitm.ac.in.
Kovai Medical Center and Hospital · INIndian Institute of Technology Madras · IN

Funding

Department of Science and Technology, Ministry of Science and Technology DST UNSKMCH Research Foundation KMCH-NNCD 2015
6 · The paper itself

Abstract

aimsIn last few decades, the prevalence of diabetes and vascular diseases has intensified concurrently with increased use of synthetic chemicals in agriculture. This study is aimed to evaluate the association of co-accumulation of arsenic and organophosphate (OP) insecticides with diabetes and atherosclerosis prevalence in a rural Indian population.

methodsThis study included observations from KMCH-NNCD-I (2015) cross-sectional study (n = 865) from an Indian farming village. The participants had assessment of clinical parameters including HbA

resultsOn multivariate regression analyses, total organophosphate level and arsenic accumulation showed association with diabetes and atherosclerosis. Higher odds ratio with significant trends were observed for the sub-quartiles formed by the combination of higher quartiles of arsenic and total organophosphates in association with diabetes and atherosclerosis.

conclusionsWe observed evidence of possible synergism between arsenic and OPs in association with prevalence of diabetes, pre-diabetes and atherosclerosis in the study population. Our findings highlight the importance of understanding health effects of mixed exposures and raises vital questions on the role of these agrochemicals in the etiology of diabetes and vascular diseases.

Indexed as

AdultAgedAged, 80 and overAgricultureArsenicAtherosclerosisCarotid Artery DiseasesCarotid Intima-Media ThicknessCross-Sectional StudiesDiabetes MellitusFemaleHumansIndiaInsecticidesMaleMiddle AgedArsenicInsecticidesOrganophosphatesArsenicAtherosclerosisDiabetesEndocrine-disrupting chemicalsOrganophosphatesRural health

Identifiers

PMID32314019
OpenAlexW3016320478

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.