Evidence map›Paper›PMID 32313974›Full record

ReviewCellular and molecular life sciences : CMLS2020

A central role of the endoplasmic reticulum in the cell emerges from its functional contact sites with multiple organelles.

Celso Almeida, Margarida D Amaral

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. The novel bacterial effector proteinbioRxiv : the preprint server for biology · 2023
    Article
  7. Review
  8. Article
  9. The endoplasmic reticulum of trypanosomatids: An unrevealed road for chemotherapy.Frontiers in cellular and infection microbiology · 2022
    Review
  10. Review
  11. Article
  12. Review
  13. ER-driven Contact Sites in Autophagosome Biogenesis Sequence.Contact (Thousand Oaks (Ventura County, Calif.))
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Celso AlmeidaFaculty of Sciences, BioISI, Biosystems and Integrative Sciences Institute, University of Lisboa, Campo Grande, C8 bdg, 1749-016, Lisbon, Portugal. cgalmeida@fc.ul.pt.ORCID http://orcid.org/0000-0002-5935-612X
Margarida D AmaralFaculty of Sciences, BioISI, Biosystems and Integrative Sciences Institute, University of Lisboa, Campo Grande, C8 bdg, 1749-016, Lisbon, Portugal. mdamaral@fc.ul.pt.ORCID http://orcid.org/0000-0002-0828-8630
University of Lisbon · PT

Funding

Bioisi UID/MULTI/04046/2019Cystic Fibrosis Trust SRC 013Fundação para a Ciência e a Tecnologia FCT/02/SAICT/2017/28800Fundação para a Ciência e a Tecnologia PTDC/BIM-MEC/2131/2014Fundação para a Ciência e a Tecnologia SFRH/BPD/77720/2011
6 · The paper itself

Abstract

Early eukaryotic cells emerged from the compartmentalization of metabolic processes into specific organelles through the development of an endomembrane system (ES), a precursor of the endoplasmic reticulum (ER), which was essential for their survival. Recently, substantial evidence emerged on how organelles communicate among themselves and with the plasma membrane (PM) through contact sites (CSs). From these studies, the ER-the largest single structure in eukaryotic cells-emerges as a central player communicating with all organelles to coordinate cell functions and respond to external stimuli to maintain cellular homeostasis. Herein we review the functional insights into the ER-CSs with other organelles in a physiological perspective. We hypothesize that, in addition to the primitive role by the ES in the appearance of proto-eukaryotes, its successor-the ER-emerges as the key coordinator of inter-organelle/PM communication. The ER thus appears to be the 'maestro' driving eukaryotic cell evolution by incorporating new functions/organelles, while remaining the real coordinator overarching cellular functions and orchestrating them with the external milieu.

Indexed as

AnimalsAutophagosomesEndoplasmic ReticulumEndosomesHumansLipid DropletsModels, BiologicalOrganellesEndosymbiosisLysosomesMitochondriaOrganellar functionsOrganelle disordersOrganelle interactions

Identifiers

PMID32313974
PMCPMC11104799
OpenAlexW3017290356

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.