Evidence map›Paper›PMID 32313885›Full record

ReviewJACC. CardioOncology2020

COVID-19 Clinical Trials: A Primer for the Cardiovascular and Cardio-Oncology Communities.

Bonnie Ky, Douglas L Mann

Abstract readReview
In one paragraph

Review in JACC. CardioOncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. COVID-19's immuno-pathology and cardiovascular diseases.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2023
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Reflections on Our Inaugural Year ofJACC. CardioOncology · 2020
    Article
  8. Renin-Angiotensin System Blockade in COVID-19: Good, Bad, or Indifferent?Journal of the American College of Cardiology · 2020
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Bonnie KyDepartment of Medicine, Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Douglas L MannDepartment of Medicine, Division of Cardiology, Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, Missouri.

Funding

ROLE OF AUTOPHAGIC FLUX IN CARDIAC MYOCYTE VIABILITYR01HL107594 · NHLBI · WASHINGTON UNIVERSITY · PI Abhinav Diwan · 2011 to 2026
$5.9M
Multimarker Risk Prediction in Cancer Therapy CardiotoxicityR01HL118018 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KY, BONNIE · 2014 to 2018
$3.7M
SALsalate to Improve Exercise toleraNce and LVDD in T2dm-DHF (SALIENT-DHF trial)U10HL110309 · NHLBI · WASHINGTON UNIVERSITY · PI DAVILA-ROMAN, VICTOR G., MANN, DOUGLAS L · 2012 to 2018
$3.5M
Planning Grant for CARISMA - Cancer therapy Risk-reduction with Intensive Systolic BP ManagementR34HL146927 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KY, BONNIE, MARGULIES, KENNETH BER · 2019 to 2020
$757k
Markers of Oxidative and Nitrosative Stress in Anthracycline Cardiotoxicity and Statin CardioprotectionR21HL141802 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KY, BONNIE · 2018 to 2019
$469k
NHLBI NIH HHS R01 HL107594NHLBI NIH HHS R01 HL118018NHLBI NIH HHS R21 HL141802NHLBI NIH HHS R34 HL146927NHLBI NIH HHS U10 HL110309
6 · The paper itself

Abstract

The coronavirus disease-2019 (COVID-19) pandemic has resulted in a proliferation of clinical trials designed to slow the spread of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Many therapeutic agents that are being used to treat patients with COVID-19 are repurposed treatments for influenza, Ebola, or for malaria that were developed decades ago and are unlikely to be familiar to the cardiovascular and cardio-oncology communities. Here, we provide a foundation for cardiovascular and cardio-oncology physicians on the front line providing care to patients with COVID-19, so that they may better understand the emerging cardiovascular epidemiology and the biological rationale for the clinical trials that are ongoing for the treatment of patients with COVID-19.

Indexed as

ACE2ACE, angiotensin-converting enzymeAT1R, angiotensin II type 1 receptorCI, confidence intervalclinical trialsCoV, coronavirusCOVID-19COVID-19, coronavirus disease-2019FDA, Food and Drug AdministrationIFN, interferonIL, interleukinIQR, interquartile rangeMERS, Middle East respiratory syndromeRAS, renin-angiotensin systemrenin angiotensin systemRNA, ribonucleic acidsACE2, soluble angiotensin-converting enzyme 2SARS-CoV-2SARS-CoV-2, severe acute respiratory syndrome-coronavirus-2TMPRSS2, transmembrane protease serine 2

Identifiers

PMID32313885
PMCPMC7164888

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.