Evidence map›Paper›PMID 32313843›Full record

ArticleNanoImpact2019

Multi-walled carbon nanotubes inhibit estrogen receptor expression in vivo and in vitro through transforming growth factor beta1.

L Cody Smith, Santiago Moreno, Sarah Robinson, Marlene Orandle, Dale W Porter, Dipesh Das, Navid B Saleh, Tara Sabo-Attwood

Open access · hybridAbstract read
In one paragraph

Article in NanoImpact, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  7. Sex and Gender Dimensions in Hazard and Risk Assessment of Engineered Nanomaterials.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

L Cody SmithDepartment of Physiological Sciences, University of Florida, Gainesville, FL.
Santiago MorenoCenter for Environmental and Human Toxicology, University of Florida, Gainesville, FL.
Sarah RobinsonCenter for Environmental and Human Toxicology, University of Florida, Gainesville, FL.
Marlene OrandleNational Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505 USA.
Dale W PorterNational Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505 USA.
Dipesh DasDepartment of Civil, Architectural and Environmental Engineering, The University of Texas at Austin, Austin, Texas.
Navid B SalehDepartment of Civil, Architectural and Environmental Engineering, The University of Texas at Austin, Austin, Texas.
Tara Sabo-AttwoodCenter for Environmental and Human Toxicology, University of Florida, Gainesville, FL.ORCID 0000-0002-1968-6802
University of Florida · USNational Institute for Occupational Safety and Health · USThe University of Texas at Austin · USUniversity of Florida Health · US

Funding

Contribution of Toll-like Receptors in the Pulmonary Response to Nanoparticles anR01HL114907 · NHLBI · UNIVERSITY OF FLORIDA · PI SABO-ATTWOOD, TARA L · 2012 to 2016
$1.5M
NHLBI NIH HHS R01 HL114907
6 · The paper itself

Abstract

Exposure to multi-walled carbon nanotubes (MWCNTs) is suspected to contribute to pulmonary fibrosis through modulation of transforming growth factor beta1 (TGF-β1). There is growing evidence that estrogen signaling is important in pulmonary function and modulates pro-fibrogenic signaling in multiple models of pulmonary fibrosis, however an interaction between MWCNT exposure and estrogen signaling in the lung is not known. The purpose of this work was to determine whether estrogen signaling in the lung is a target for MWCNTs and to identify potential signaling mechanisms mediating MWCNT-induced responses using a whole-body inhalation mouse model and an

Indexed as

estrogen receptorlungMulti-walled carbon nanotubetransforming growth factor beta1

Identifiers

PMID32313843
PMCPMC7169977
OpenAlexW2922786952

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.