ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020
Amyloid β influences the relationship between cortical thickness and vascular load.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Retention and longitudinal change in Insight 46, an intensive neuroscience sub-study of the 1946 British birth cohort.BMC research notes · 2026Article
- The relationship between leisure time physical activity patterns, Alzheimer's disease markers and cognition.Brain communications · 2025Article
- The relationship between cortical thickness and white matter hyperintensities in mid to late life.Neurobiology of aging · 2024Article
- Rates of cortical thinning in Alzheimer's disease signature regions associate with vascular burden but not with β-amyloid status in cognitively normal adults at age 70.Journal of neurology, neurosurgery, and psychiatry · 2024Article
- Updating the study protocol: Insight 46 - a longitudinal neuroscience sub-study of the MRC National Survey of Health and Development - phases 2 and 3.BMC neurology · 2024Article
- Longitudinal associations between β-amyloid and cortical thickness in mild cognitive impairment.Brain communications · 2023Article
- Clinical outcomes of increased focal amyloid uptake in individuals with subthreshold global amyloid levels.Frontiers in aging neuroscience · 2023Article
- Cortical thickness is differently associated with ALDH2 rs671 polymorphism according to level of amyloid deposition.Scientific reports · 2021Article
- A population-based study of head injury, cognitive function and pathological markers.Annals of clinical and translational neurology · 2021Article
- Amyloid β influences the relationship between cortical thickness and vascular load.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 1 country.
Funding
Abstract
introductionCortical thickness has been proposed as a biomarker of Alzheimer's disease (AD)- related neurodegeneration, but the nature of its relationship with amyloid beta (Aβ) deposition and white matter hyperintensity volume (WMHV) in cognitively normal adults is unclear.
methodsWe investigated the influences of Aβ status (negative/positive) and WMHV on cortical thickness in 408 cognitively normal adults aged 69.2 to 71.9 years who underwent
resultsHigher WMHV, but not Aβ status, predicted lower cortical thickness across all participants, in all ROIs. Conversely, when Aβ-positive participants were considered alone, higher WMHV predicted higher cortical thickness in a temporal AD-signature region. DISCUSSION: WMHV may differentially influence cortical thickness depending on the presence or absence of Aβ, potentially reflecting different pathological mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.