ReviewJournal of medical imaging (Bellingham, Wash.)2020
Virtual clinical trials in medical imaging: a review.
Review in Journal of medical imaging (Bellingham, Wash.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
131 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring the potential of computer simulation models in drug testing and biomedical research: a systematic review.Frontiers in pharmacology · 2025Pooled it
- A virtual imaging framework for three-dimensional quantitative optoacoustic tomography using stochastic numerical breast phantoms.Photoacoustics · 2026Article
- Stochastic numerical head phantoms to enable virtual imaging studies of transcranial photoacoustic computed tomography.Photoacoustics · 2026Article
- The Next Frontier in Quantitative Co-Clinical Imaging to Advance Functional Precision Oncology.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- The Accuracy of Noise Measurements in Patient CT Images.Academic radiology · 2026Article
- An integrated PET/CT simulation framework for virtual imaging trials and quantitative performance evaluation.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2026Article
- The Uncoupling of CT Dose and Noise.Radiology · 2026Article
- In Silico Digital Breast Tomosynthesis Dataset for the Comparative Analysis of Deep Learning Models in Tumor Segmentation.Journal of imaging informatics in medicine · 2026Article
- Improving visibility of small anatomical details on low and ultra-low dose computed tomography with artificial intelligence-based image reconstructions.Radiation protection dosimetry · 2026Article
- X-Ray Attenuation Properties of Additive Manufacturing and 3D Printing Materials for Mimicking Tissues in Radiographic Phantoms Measured by CT from 70 to 140 kV: 2025 Update.Biomimetics (Basel, Switzerland) · 2026Article
- Demographic distribution matching between real-world and virtual phantom population.Medical physics · 2026Article
- An in silico evaluation of signal and separability properties of k-edge materials in spectral CT.Scientific reports · 2026Article
- Conditional generative diffusion model for 3D trabecular bone synthesis with tunable microstructure.Journal of medical imaging (Bellingham, Wash.) · 2026Article
- A Generative Model of Lung CT Conditioned on Radiomics Features.Proceedings of SPIE--the International Society for Optical Engineering · 2026Article
- Virtual Imaging-Guided Harmonization of Chest X-rays Using a Generative Adversarial Neural Network.IEEE transactions on bio-medical engineering · 2026Article
- Comparing evaluation of quantitative imaging methods using reference standards versus regression‑without‑truth‑based technique.Proceedings of SPIE--the International Society for Optical Engineering · 2026Article
- From images to physics-based computational models to digital twins: a framework for personalized cancer therapies.Frontiers in radiology · 2026Article
- Airway quantifications of bronchitis patients with photon-counting and energy-integrating computed tomography.Journal of medical imaging (Bellingham, Wash.) · 2026Article
- Generation of multimodal realistic computational phantoms as a test-bed for validating deep learning-based cross-modality synthesis techniques.Medical & biological engineering & computing · 2026Article
- Utility of the virtual imaging trials methodology for objective characterization of AI systems and training data.Journal of medical imaging (Bellingham, Wash.) · 2026Article
71 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
The accelerating complexity and variety of medical imaging devices and methods have outpaced the ability to evaluate and optimize their design and clinical use. This is a significant and increasing challenge for both scientific investigations and clinical applications. Evaluations would ideally be done using clinical imaging trials. These experiments, however, are often not practical due to ethical limitations, expense, time requirements, or lack of ground truth. Virtual clinical trials (VCTs) (also known as
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.