ReviewCureus2020
Acute C4 Ingestion and Toxicity: Presentation and Management.
Review in Cureus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- A Mind-Blowing Ingestion: Intentional Plastic Explosive Consumption Resulting in Seizures.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2025Article
- Simultaneous Determination of RDX and HMX in Rat Plasma by LC-MS/MS and its Applications.Frontiers in chemistry · 2022Article
- Peer Pressure = Explosive Consequences: A Case Report of Toxic Ingestion of Cyclonite (C-4) Explosive on a Dare.Clinical practice and cases in emergency medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Composition C4 is a plastic explosive substance used in military combat units for demolition. The active component of composition C4 is hexahydro-1,3,5-trinitro-1,3,5-triazine, also known as RDX (Royal Demolition Explosive). There are limited reports of the effects of ingested C4. We sought to provide a broad overview of cyclonite/RDX exposure in humans to give a general understanding of both the clinical effects of exposure as well as management considerations. The authors searched MEDLINE and Google Scholar for articles using the keywords for this literature review, including case reports, case series, animal studies, clinical guidelines, and reviews. There are few reports and studies of C4 ingestion. In these studies, the most common effects are serious central nervous system (CNS) effects followed by renal and gastrointestinal symptoms. Critical actions involve airway control, seizure control, and adequate fluid hydration. The toxidrome of this ingestion is typically transient and management is primarily supportive.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.