Evidence map›Paper›PMID 32313663›Full record

ArticleCanadian journal of kidney health and disease2020

Mortality and Morbidity in Kidney Transplant Recipients With a Failing Graft: A Matched Cohort Study.

Ngan N Lam, Devon J Boyne, Robert R Quinn, Peter C Austin, Brenda R Hemmelgarn, Patricia Campbell, Gregory A Knoll, Lee Anne Tibbles, Serdar Yilmaz, Hude Quan and 1 more

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In one paragraph

Article in Canadian journal of kidney health and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ngan N LamCumming School of Medicine, Division of Nephrology, University of Calgary, AB, Canada.ORCID https://orcid.org/0000-0002-0129-7091
Devon J BoyneCumming School of Medicine, Division of Nephrology, University of Calgary, AB, Canada.
Robert R QuinnCumming School of Medicine, Division of Nephrology, University of Calgary, AB, Canada.
Peter C AustinICES, Toronto, ON, Canada.
Brenda R HemmelgarnCumming School of Medicine, Division of Nephrology, University of Calgary, AB, Canada.
Patricia CampbellDepartment of Medicine, Division of Nephrology, University of Alberta, Edmonton, Canada.
Gregory A KnollClinical Epidemiology Program, Ottawa Hospital Research Institute, ON, Canada.
Lee Anne TibblesCumming School of Medicine, Division of Nephrology, University of Calgary, AB, Canada.
Serdar YilmazDepartment of Surgery, Division of Transplantation, University of Calgary, AB, Canada.
Hude QuanDepartment of Community Health Sciences, University of Calgary, AB, Canada.
Pietro RavaniCumming School of Medicine, Division of Nephrology, University of Calgary, AB, Canada.ORCID https://orcid.org/0000-0001-6973-8570

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDue to their history of renal disease and exposure to immunosuppression, kidney transplant recipients with a failing graft may be at higher risk of adverse outcomes compared to nontransplant controls. Understanding the burden of disease in transplant recipients may inform treatment decisions of people whose native kidneys are failing and may be eligible for a transplant.

objectiveTo compare mortality and morbidity in kidney transplant recipients with a failing graft to matched nontransplant controls.

designRetrospective cohort study.

settingAlberta, Canada. PATIENTS: Kidney transplant recipients with a failing graft were identified as having at least 2 estimated glomerular filtration rate (eGFR) measurements between 15-30 mL/min/1.73 m MEASUREMENTS: Mortality and hospitalization.

methodsWe propensity-score matched 520 kidney transplant recipients with a failing graft to 520 nontransplant controls.

resultsThe median age of the matched cohort was 57 years and 40% were women. Compared to matched nontransplant controls, recipients with a failing graft had a higher hazard of death (hazard ratio, 1.54; 95% confidence interval [CI], 1.28-1.85; LIMITATIONS: Observational design with the risk of residual confounding.

conclusionsA failing kidney transplant is associated with an increased burden of mortality and morbidity beyond chronic kidney disease. This information may assist the discussion of prognosis in kidney transplant recipients with a failing graft and the design of strategies to minimize risks.

Indexed as

AlbertaCKD (chronic kidney disease)estimated glomerular filtration ratekidney transplantationmortality

Identifiers

PMID32313663
PMCPMC7158256

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.