Evidence map›Paper›PMID 32313543›Full record

ArticleAdvanced functional materials2018

Host Cell Mimic Polymersomes for Rapid Detection of Highly Pathogenic Influenza Virus via a Viral Fusion and Cell Entry Mechanism.

Hyun-Ouk Kim, Woonsung Na, Minjoo Yeom, Jihye Choi, Jihye Kim, Jong-Woo Lim, Dayeon Yun, Haejin Chun, Geunseon Park, Chaewon Park and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in Advanced functional materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 3 countries.

Hyun-Ouk KimDepartment of Chemical & Biomolecular Engineering Yonsei University Seoul 03722 Republic of Korea.
Woonsung NaDepartment of Pharmacy College of Pharmacy Korea University Sejong 30019 Republic of Korea.
Minjoo YeomDepartment of Pharmacy College of Pharmacy Korea University Sejong 30019 Republic of Korea.
Jihye ChoiResearch Institute of Radiological Science College of Medicine Yonsei University Seoul 03722 Republic of Korea.
Jihye KimDepartment of Chemical & Biomolecular Engineering Yonsei University Seoul 03722 Republic of Korea.
Jong-Woo LimDepartment of Chemical & Biomolecular Engineering Yonsei University Seoul 03722 Republic of Korea.
Dayeon YunDepartment of Chemical & Biomolecular Engineering Yonsei University Seoul 03722 Republic of Korea.
Haejin ChunDepartment of Chemical & Biomolecular Engineering Yonsei University Seoul 03722 Republic of Korea.
Geunseon ParkDepartment of Chemical & Biomolecular Engineering Yonsei University Seoul 03722 Republic of Korea.
Chaewon ParkDepartment of Chemical & Biomolecular Engineering Yonsei University Seoul 03722 Republic of Korea.
Jeong-Ki KimDepartment of Pharmacy College of Pharmacy Korea University Sejong 30019 Republic of Korea.
Dae Gwin JeongInfectious Disease Research Center Korea Research Institute of Bioscience and Biotechnology Daejeon 34141 South Korea.
Van Phan LeDepartment of Microbiology and Infectious Diseases College of Veterinary Medicine Vietnam National University of Agriculture Hanoi 100000 Vietnam.
Kwangyeol LeeDepartment of Chemistry Korea University Seoul 02841 Republic of Korea.
Jae Myun LeeDepartment of Microbiology Yonsei University College of Medicine Seoul 03722 Republic of Korea.
Hyoung Hwa JeongHuVet bio, Inc. Seoul 06646 Republic of Korea.
Daesub SongDepartment of Pharmacy College of Pharmacy Korea University Sejong 30019 Republic of Korea.
Seungjoo HaamDepartment of Chemical & Biomolecular Engineering Yonsei University Seoul 03722 Republic of Korea.ORCID 0000-0002-8245-7148
Yonsei University · KRKorea University · KRBio-Medical Science (South Korea) · KRKorea Research Institute of Bioscience and Biotechnology · KRVietnam National University of Agriculture · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Highly pathogenic avian influenza virus (HPAIV) infections have occurred continuously and crossed the species barrier to humans, leading to fatalities. A polymerase chain reaction based molecular test is currently the most sensitive diagnostic tool for HPAIV; however, the results must be analyzed in centralized diagnosis systems by a trained individual. This requirement leads to delays in quarantine and isolation. To control the spread of HPAIV, rapid and accurate diagnostics suitable for field testing are needed, and the tests must facilitate a differential diagnosis between HPAIV and low pathogenic avian influenza virus (LPAIV), which undergo cleavage specifically by trypsin- or furin-like proteases, respectively. In this study, a differential avian influenza virus rapid test kit is developed and evaluated in vitro and using clinical specimens from HPAIV H5N1-infected animals. It is demonstrated that this rapid test kit provides highly sensitive and specific detection of HPAIV and LPAIV and is thus a useful field diagnostic tool for H5N1 HPAIV outbreaks and for rapid quarantine control of the disease.

Indexed as

cell mimicshighly pathogenic avian influenza virus (HPAIV)influenza A viruspoint‐of‐care testing (POCT)polymersomes

Identifiers

PMID32313543
PMCPMC7161833
OpenAlexW2810872895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.