Evidence map›Paper›PMID 32313479›Full record

ArticleProceedings (Baylor University. Medical Center)2020

Hyperammonemic encephalopathy associated with 5-fluorouracil in a patient with previous orthotopic liver transplantation.

Hemnishil K Marella, Rahul Peravali, Amit L Jain, Satheesh Nair, Benedict Maliakkal, Uchenna Agbim, Rajanshu Verma

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings (Baylor University. Medical Center), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hemnishil K MarellaDepartment of Gastroenterology and Hepatology, College of Medicine, The University of Tennessee Health Science Center MemphisTennessee.
Rahul PeravaliDepartment of Gastroenterology and Hepatology, College of Medicine, The University of Tennessee Health Science Center MemphisTennessee.
Amit L JainDepartment of Gastroenterology and Hepatology, College of Medicine, The University of Tennessee Health Science Center MemphisTennessee.
Satheesh NairDepartment of Gastroenterology and Hepatology, College of Medicine, The University of Tennessee Health Science Center MemphisTennessee.
Benedict MaliakkalDepartment of Gastroenterology and Hepatology, College of Medicine, The University of Tennessee Health Science Center MemphisTennessee.
Uchenna AgbimDepartment of Gastroenterology and Hepatology, College of Medicine, The University of Tennessee Health Science Center MemphisTennessee.
Rajanshu VermaDepartment of Gastroenterology and Hepatology, College of Medicine, The University of Tennessee Health Science Center MemphisTennessee.
University of Tennessee Health Science Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

5-Fluorouracil (5-FU)-based chemotherapy is the most common regimen used to treat metastatic or advanced colon cancer. Neurotoxicity is a rare but serious adverse effect of 5-FU-based therapy. We report an unusual case of 5-FU-induced hyperammonemic encephalopathy in a patient with recurrent colon cancer that metastasized to the liver and lung. Two days after receiving the third dose of FOLFOX, he presented with altered mental status, agitation, abdominal pain, nausea, and vomiting. His total ammonia level was 434 μmol/L, for which he was treated with lactulose retention enema and lactulose via nasogastric tube. Over the next 24 hours, his condition improved significantly.

Indexed as

5-fluorouracilColon cancerhyperammonemic encephalopathy

Identifiers

PMID32313479
PMCPMC7155959
OpenAlexW3000610122

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.