Trial reportNature protocols2020
Simultaneous noninvasive recording of electrocardiogram and skin sympathetic nerve activity (neuECG).
Trial report in Nature protocols, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 110 citations in OpenAlex.
- Acute Effects of Resonance Breathing on Skin Sympathetic Nerve Activity and Heart Rate Variability in Healthy Adults.Applied psychophysiology and biofeedback · 2025Trial
- Skin Sympathetic Nerve Activity After Pulsed Field Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation: The NEU-PFA Study.Circulation. Arrhythmia and electrophysiology · 2026Article
- Complexity Analysis of Skin Nerve Activity for Quantitative Assessment of Acute Sympathetic Nervous System Activation.Sensors (Basel, Switzerland) · 2026Article
- α2δ-1-NMDAR1 complex in the hypothalamic paraventricular nucleus mediates anxiety-induced sympathetic hyperactivity.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Interplay between Skin Sympathetic Nerve Activity and Gut Microbiota, the Neurocardiac Axis in Acute Coronary Syndrome.International journal of medical sciences · 2026Article
- Pupillary ultrasonography vs Horner's syndrome to evaluate efficacy of stellate ganglion block in patients.IBRO neuroscience reports · 2025Article
- Prediction of intradialytic hypotension based on heart rate variability and skin sympathetic nerve activity using LASSO-enabled feature selection: a two-center study.Renal failure · 2025Article
- Mortality prediction in hemodialysis patients using heart rate variability and skin sympathetic nerve activity.Renal failure · 2025Article
- Article
- Skin sympathetic nerve activity: Potential new non-invasive indicator of exercise metabolic thresholds in adults.Physiological reports · 2025Article
- Article
- Triglyceride-glucose index is associated with silent cerebral infarcts in patients with atrial fibrillation undergoing catheter ablation.BMC cardiovascular disorders · 2025Article
- Combination of skin sympathetic nerve activity and urine biomarkers in improving diagnostic accuracy for urge urinary incontinence.Scientific reports · 2025Article
- Effects of Pulmonary Vein Isolation for Atrial Fibrillation on Skin Sympathetic Nerve Activity in Association with Left Atrial Remodeling.Journal of cardiovascular development and disease · 2025Article
- The Vagus Nerve as a Gateway to Body Ownership: taVNS Reduces Susceptibility to a Virtual Version of the Cardiac and Tactile Rubber Hand Illusion.Psychophysiology · 2025Article
- Association between skin sympathetic nerve activity and electrocardiogram alterations after subarachnoid hemorrhage.Physiological reports · 2025Article
- Autonomic Nervous Regulation was Associated with Sleep Quality Among Peritoneal Dialysis Patients.Nature and science of sleep · 2025Article
- Skin sympathetic nerve activity in symptomatic and asymptomatic paroxysmal atrial fibrillation.Heart rhythm · 2024Article
- Higher skin sympathetic nerve activity as a potential predictor of overactive bladder in females refractory to oral monotherapy.The Kaohsiung journal of medical sciences · 2024Article
- Renal denervation for hypertensive heart disease and atrial fibrillation.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 10 institutions in 4 countries.
Funding
Abstract
neuECG, the simultaneous noninvasive recording of ECG and skin sympathetic nerve activity (SKNA), directly records sympathetic nerve activity over a long period of time. It can be used to measure sympathetic tone in healthy subjects and in subjects with non-cardiovascular diseases. The electrical activity that can be measured on the surface of the skin originates from the heart, the muscle or nerve structures. Because the frequency content of nerve activity falls in a higher frequency range than that of the ECG and myopotential, it is possible to use high-pass or band-pass filtering to specifically isolate the SKNA. neuECG is voltage calibrated and does not require invasive procedures to impale electrodes in nerves and thus has advantages over microneurography. Here, we present a protocol that takes <10 min to set up. The neuECG can be continuously recorded over a 24-h period or longer. We also describe methods to efficiently analyze neuECG from humans using commercially available hardware and software to facilitate adoption of this technology in clinical research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.