ArticleNature human behaviour2020
Neurobehavioural characterisation and stratification of reinforcement-related behaviour.
Article in Nature human behaviour, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- A sequential dual-site repetitive transcranial magnetic stimulation for major depressive disorder: A randomized clinical trial.Cell reports. Medicine · 2025Trial
- A longitudinal DNA methylation atlas and its link to brain structure and mental health.Molecular psychiatry · 2026Article
- Brain network-based stratification of mental health disorders: design and cohort description of the STRATIFY and ESTRA studies.Molecular psychiatry · 2026Review
- Neurocognitive characterization of behaviour and mental illness through time-varying brain network analysis.Nature communications · 2026Article
- Multimodal Investigations of Structural and Functional Brain Alterations in Anorexia and Bulimia Nervosa and Their Relationships to Psychopathology.Biological psychiatry · 2025Article
- A Novel Diathesis-Stress Model of Comorbid Early Onset Psychiatric Disorders.medRxiv : the preprint server for health sciences · 2025Article
- Brain imaging of a gamified cognitive flexibility task in young and older adults.Brain imaging and behavior · 2024Article
- Evaluation of behavioral variance/covariance explained by the neuroimaging data through a pattern-based regression.Human brain mapping · 2024Article
- Evaluating the development and well-being assessment (DAWBA) in pediatric anxiety and depression.Child and adolescent psychiatry and mental health · 2024Article
- A general neuropsychopathological factor underlying many mental illnesses.Nature medicine · 2023Article
- A shared neural basis underlying psychiatric comorbidity.Nature medicine · 2023Article
- Pubertal timing and functional neurodevelopmental alterations independently mediate the effect of family conflict on adolescent psychopathology.Developmental cognitive neuroscience · 2021Article
- [IMAGEN and beyond: novel population neuroscientific strategies for clinical and global cohorts in the STRATIFY and GIGA consortia].Der Nervenarzt · 2021Review
- [Potentials and limits of aging cohort studies for geriatric psychiatry].Der Nervenarzt · 2021Review
- Neural Biomarkers Distinguish Severe From Mild Autism Spectrum Disorder Among High-Functioning Individuals.Frontiers in human neuroscience · 2021Article
Corrections and comments
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Authors and funding
31 authors at 14 institutions in 7 countries.
Funding
Abstract
Reinforcement-related cognitive processes, such as reward processing, inhibitory control and social-emotional regulation are critical components of externalising and internalising behaviours. It is unclear to what extent the deficit in each of these processes contributes to individual behavioural symptoms, how their neural substrates give rise to distinct behavioural outcomes and whether neural activation profiles across different reinforcement-related processes might differentiate individual behaviours. We created a statistical framework that enabled us to directly compare functional brain activation during reward anticipation, motor inhibition and viewing emotional faces in the European IMAGEN cohort of 2,000 14-year-old adolescents. We observe significant correlations and modulation of reward anticipation and motor inhibition networks in hyperactivity, impulsivity, inattentive behaviour and conduct symptoms, and we describe neural signatures across cognitive tasks that differentiate these behaviours. We thus characterise shared and distinct functional brain activation patterns underling different externalising symptoms and identify neural stratification markers, while accounting for clinically observed comorbidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.