Evidence map›Paper›PMID 32313136›Full record

ArticleScientific reports2020

RNA Sequence Analyses throughout the Course of Mouse Cardiac Laminopathy Identify Differentially Expressed Genes for Cell Cycle Control and Mitochondrial Function.

Zhili Shao, Wonshill Koh, Ying Ni, Wei Li, Brendan Agatisa-Boyle, Daria Merkurjev, Wai Hong Wilson Tang

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Targeting Mitochondria Dysfunction in LMNA Cardiomyopathy.JACC. Basic to translational science · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Zhili ShaoDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Wonshill KohDepartment of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Ying NiDepartment of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Wei LiDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.
Brendan Agatisa-BoyleDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Daria MerkurjevDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Wai Hong Wilson TangDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. tangw@ccf.org.
Cleveland Clinic Lerner College of Medicine · USCincinnati Children's Hospital Medical Center · USCleveland Clinic · USMarshall University · USUniversity of California, Los Angeles · US

Funding

Nitrative stress in heart failureR01HL103931 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI TANG, WAI HONG WILSON · 2010 to 2014
$3.8M
NHLBI NIH HHS R01 HL103931
6 · The paper itself

Abstract

Lamin A/C (LMNA) gene mutations are a known cause of familial dilated cardiomyopathy, but the precise mechanisms triggering disease progression remain unknown. We hypothesize that analysis of differentially expressed genes (DEGs) throughout the course of Lmna knockout (Lmna

Indexed as

DNA RepairAction PotentialsAnimalsCardiomyopathy, DilatedCell CycleCell SurvivalDisease Models, AnimalDisease ProgressionDNA DamageGene Expression ProfilingGene Expression RegulationHumansLamin Type AMiceMice, Inbred C57BLMice, KnockoutLamin Type ALMNA protein, humanLmna protein, mouse

Identifiers

PMID32313136
PMCPMC7170950
OpenAlexW3017109472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.