ArticleNature biomedical engineering2020
Stabilization of a brain-computer interface via the alignment of low-dimensional spaces of neural activity.
Article in Nature biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
97 citing papers in PubMed, 221 citations in OpenAlex.
- How different immersive environments affect intracortical brain computer interfaces.Journal of neural engineering · 2025Trial
- Neural subspaces of imagined movements in parietal cortex remain stable over several years in humans.Journal of neural engineering · 2024Trial
- Prioritized nonlinear modeling of shared dynamics across neural populations.Journal of neural engineering · 2026Article
- Realignment of representational drift in mouse visual cortex via flexible electrode arrays.Nature biomedical engineering · 2026Article
- Human learning of noninvasive brain-computer interfaces via manifold geometry.Nature neuroscience · 2026Article
- Article
- Advancing data protections for implantable brain-computer interfaces.Communications medicine · 2026Review
- Learning-related population dynamics in right and left dorsal premotor cortex during typing skill acquisition.bioRxiv : the preprint server for biology · 2026Article
- Long-term unsupervised recalibration of cursor-based intracortical brain-computer interfaces using a hidden Markov model.Nature biomedical engineering · 2026Article
- Article
- Decoupling simultaneous motor imagination and execution via orthogonal ECoG neural representations.Nature communications · 2026Article
- Integrating living biomaterials into neuroelectronic systems.Biomedical engineering letters · 2026Review
- Closed-loop error damping in human BCI using pre-error motor cortex activity.bioRxiv : the preprint server for biology · 2026Article
- Cross-subject mapping of neural activity with restricted Boltzmann machines.Frontiers in computational neuroscience · 2026Article
- Long-term Intracortical Neural activity and Kinematics (LINK): An intracortical neural dataset for chronic brain-machine interfaces, neuroscience, and machine learning.Advances in neural information processing systems · 2025Article
- Ethical imperatives in the commercialization of brain-computer interfaces.IBRO neuroscience reports · 2025Article
- Decoding multi-joint hand movements from brain signals by learning a synergy-based neural manifold.Patterns (New York, N.Y.) · 2025Article
- The spatiotemporal structure of neural activity in motor cortex during reaching.bioRxiv : the preprint server for biology · 2025Article
- Signal properties and stability of a chronically implanted endovascular brain computer interface.medRxiv : the preprint server for health sciences · 2025Article
- Article
37 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The instability of neural recordings can render clinical brain-computer interfaces (BCIs) uncontrollable. Here, we show that the alignment of low-dimensional neural manifolds (low-dimensional spaces that describe specific correlation patterns between neurons) can be used to stabilize neural activity, thereby maintaining BCI performance in the presence of recording instabilities. We evaluated the stabilizer with non-human primates during online cursor control via intracortical BCIs in the presence of severe and abrupt recording instabilities. The stabilized BCIs recovered proficient control under different instability conditions and across multiple days. The stabilizer does not require knowledge of user intent and can outperform supervised recalibration. It stabilized BCIs even when neural activity contained little information about the direction of cursor movement. The stabilizer may be applicable to other neural interfaces and may improve the clinical viability of BCIs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.