ArticleNature communications2020
Real-time non-contact cellular imaging and angiography of human cornea and limbus with common-path full-field/SD OCT.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 41 citations in OpenAlex.
- Enhancing biomedical optical volumetric imaging via self-supervised orthogonal learning.Science advances · 2026Article
- High-resolution dynamic full-field optical coherence microscopy: illuminating intracellular activity in deep tissue.Npj imaging · 2026Article
- Transmission interference microscopy of anterior human eye.Nature communications · 2025Article
- Correlation of Multimodal Clinical Imaging With the Whole-Slide- and Superresolution-Based Immunohistological Structure of the Corneal Limbal Stroma.Investigative ophthalmology & visual science · 2025Article
- Review
- Improved tracking of corneal immune cell dynamics usingBiomedical optics express · 2024Article
- In vivo, contactless, cellular resolution imaging of the human cornea with Powell lens based line field OCT.Scientific reports · 2024Article
- Cellular structural and functional imaging of donor and pathological corneas with label-free dual-mode full-field optical coherence tomography.Biomedical optics express · 2024Article
- Real-time line-field optical coherence tomography for cellular resolution imaging of biological tissue.Biomedical optics express · 2024Article
- Optical tomography in a single camera frame using fringe-encoded deep-learning full-field OCT.Biomedical optics express · 2024Article
- Comparative analysis of full-field OCT and optical transmission tomography.Biomedical optics express · 2023Article
- Non-invasiveBiomedical optics express · 2023Article
- Optical Flow-Based Full-Field Quantitative Blood-Flow Velocimetry Using Temporal Direction Filtering and Peak Interpolation.International journal of molecular sciences · 2023Article
- In-vivo corneal confocal microscopy: Imaging analysis, biological insights and future directions.Communications biology · 2023Review
- N-mirror Robot System for Laser Surgery: A Simulation Study.... International Symposium on Medical Robotics. International Symposium on Medical Robotics · 2023Article
- Dynamic full-field optical coherence tomography for live-cell imaging and growth-phase monitoring inFrontiers in cellular and infection microbiology · 2023Article
- Advancements in high-resolution imaging of the iridocorneal angle.Frontiers in ophthalmology · 2023Review
- Corneal imaging with blue-light optical coherence microscopy.Biomedical optics express · 2022Article
- Label free optical transmission tomography for biosystems: intracellular structures and dynamics.Biomedical optics express · 2022Article
- Line-scanning SD-OCT forBiomedical optics express · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In today's clinics, a cell-resolution view of the cornea can be achieved only with a confocal microscope (IVCM) in contact with the eye. Here, we present a common-path full-field/spectral-domain OCT microscope (FF/SD OCT), which enables cell-detail imaging of the entire ocular surface in humans (central and peripheral cornea, limbus, sclera, tear film) without contact and in real-time. Real-time performance is achieved through rapid axial eye tracking and simultaneous defocusing correction. Images contain cells and nerves, which can be quantified over a millimetric field-of-view, beyond the capability of IVCM and conventional OCT. In the limbus, palisades of Vogt, vessels, and blood flow can be resolved with high contrast without contrast agent injection. The fast imaging speed of 275 frames/s (0.6 billion pixels/s) allows direct monitoring of blood flow dynamics, enabling creation of high-resolution velocity maps. Tear flow velocity and evaporation time can be measured without fluorescein administration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.