Evidence map›Paper›PMID 32313047›Full record

ArticleNPJ schizophrenia2020

Language in schizophrenia: relation with diagnosis, symptomatology and white matter tracts.

J N de Boer, M van Hoogdalem, R C W Mandl, J Brummelman, A E Voppel, M J H Begemann, E van Dellen, F N K Wijnen, I E C Sommer

Abstract read
In one paragraph

Article in NPJ schizophrenia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Structural neuroimaging correlates of semantic incoherence in schizophrenia.European archives of psychiatry and clinical neuroscience · 2026
    Article
  5. Article
  6. Article
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  8. Linking spontaneous speech, cognition, and psychopathology across affective and psychotic disorders: A network approach.European psychiatry : the journal of the Association of European Psychiatrists · 2026
    Article
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

J N de BoerDepartment of Psychiatry, University Medical Center Utrecht, Utrecht University & Brain Center Rudolf Magnus, Utrecht, The Netherlands. j.n.deboer-15@umcutrecht.nl.
M van HoogdalemDepartment of Psychiatry, University Medical Center Utrecht, Utrecht University & Brain Center Rudolf Magnus, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-1821-5790
R C W MandlDepartment of Psychiatry, University Medical Center Utrecht, Utrecht University & Brain Center Rudolf Magnus, Utrecht, The Netherlands.
J BrummelmanDepartment of Psychiatry, University Medical Center Utrecht, Utrecht University & Brain Center Rudolf Magnus, Utrecht, The Netherlands.
A E VoppelDepartment of Neuroscience and Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
M J H BegemannDepartment of Neuroscience and Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
E van DellenDepartment of Psychiatry, University Medical Center Utrecht, Utrecht University & Brain Center Rudolf Magnus, Utrecht, The Netherlands.
F N K WijnenUtrecht Institute of Linguistics OTS, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-7196-6000
I E C SommerDepartment of Neuroscience and Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Language deviations are a core symptom of schizophrenia. With the advances in computational linguistics, language can be easily assessed in exact and reproducible measures. This study investigated how language characteristics relate to schizophrenia diagnosis, symptom, severity and integrity of the white matter language tracts in patients with schizophrenia and healthy controls. Spontaneous speech was recorded and diffusion tensor imaging was performed in 26 schizophrenia patients and 22 controls. We were able to classify both groups with a sensitivity of 89% and a specificity of 82%, based on mean length of utterance and clauses per utterance. Language disturbances were associated with negative symptom severity. Computational language measures predicted language tract integrity in patients (adjusted R

Identifiers

PMID32313047
PMCPMC7171150

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.