ArticleNature communications2020
A fungal pathogen induces systemic susceptibility and systemic shifts in wheat metabolome and microbiome composition.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
79 citing papers in PubMed, 1 synthesis or guideline pooled it, 183 citations in OpenAlex.
- Priority actions for Fusarium head blight resistance in durum wheat: Insights from the wheat initiative.The plant genome · 2025Pooled it
- Exploring the antifungal activity of the wheat microbiome.Biochemical Society transactions · 2026Review
- Thiamine cross-feeding drives microbial coexistence in the leaf microbiome.Nature microbiology · 2026Article
- Review
- Article
- Mycobiome Simplification in Wheat Is Associated With the Pathogen Parastagonospora nodorum.Molecular ecology · 2026Article
- Multi-omics of barley Fusarium Head Blight converge on pathogen-triggered biosynthesis of aromatic amino acid derived chemical defense compounds.Stress biology · 2026Article
- Isolation, Identification, and Diversity Analysis of Endophytic Fungi from Sweetpotato.Journal of fungi (Basel, Switzerland) · 2026Article
- Genome-host association mapping reveals wheat pathogen genes involved in host specialization.Nature plants · 2026Article
- The Anna Karenina principle in the assembly of plant microbiome under pathogen stress.NPJ biofilms and microbiomes · 2026Article
- When Metabolomics Meets Quantitative Genetics: An Integrative Strategy to Elucidate Plant Resistance Mechanisms.Plant, cell & environment · 2026Review
- The effect of biological control on mycotoxin concentrations and the mycobiome in durum wheat grain and stems.Scientific reports · 2026Article
- Comprehensive metabolomic characterization of defense reprogramming in Castanea mollissima under Oligonychus ununguis feeding stress.PloS one · 2026Article
- Genotype-specific root morphology and metabolic traits shape bacterial communities and tolerance to Fusarium root rot in wheat.PloS one · 2026Article
- High-resolution profiling of bacterial and fungal communities using pangenome-informed taxon-specific long-read amplicons.Microbiome · 2025Article
- Functional dynamics reveal the response of the crabapple (mSystems · 2025Article
- Advancing forest pathology: the need for community-driven molecular experimental model systems.The New phytologist · 2025Review
- A Simplified and Integrated View of Disease Control in Varietal Mixtures Using the Phytobiome Framework.Plant, cell & environment · 2025Review
- Metabolite-mediated responses of phyllosphere microbiota to powdery mildew infection in resistant and susceptible black currant cultivars.Horticulture research · 2025Article
- Changes in the assembly and functional adaptation of endophytic microbial communities in Amorphophallus species with different levels of resistance to necrotrophic bacterial pathogen stress.Communications biology · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Yield losses caused by fungal pathogens represent a major threat to global food production. One of the most devastating fungal wheat pathogens is Zymoseptoria tritici. Despite the importance of this fungus, the underlying mechanisms of plant-pathogen interactions are poorly understood. Here we present a conceptual framework based on coinfection assays, comparative metabolomics, and microbiome profiling to study the interaction of Z. tritici in susceptible and resistant wheat. We demonstrate that Z. tritici suppresses the production of immune-related metabolites in a susceptible cultivar. Remarkably, this fungus-induced immune suppression spreads within the leaf and even to other leaves, a phenomenon that we term "systemic induced susceptibility". Using a comparative metabolomics approach, we identify defense-related biosynthetic pathways that are suppressed and induced in susceptible and resistant cultivars, respectively. We show that these fungus-induced changes correlate with changes in the wheat leaf microbiome. Our findings suggest that immune suppression by this hemibiotrophic pathogen impacts specialized plant metabolism, alters its associated microbial communities, and renders wheat vulnerable to further infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.