ArticleNature communications2020
Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 51 citations in OpenAlex.
- Auditory associative learning drives synaptic responses in tail of the striatum spiny projection neurons.iScience · 2026Article
- Indirect pathway neurons in the tail of the striatum regulate inhibitory control over sensory driven behavior.Science advances · 2026Article
- Prefrontal cortex interneurons and their contributions to attention, working memory, and adaptive behavior.Progress in neurobiology · 2026Review
- Lateral habenula and periaqueductal gray neurons signal reward prediction error and continuity of reward expectancy to drive reward-seeking behavior.Cell reports · 2026Article
- Multiple groups of neurons in the superior colliculus convert value signals into saccadic vigor.iScience · 2026Article
- A Distinct Circuit for Biasing Visual Perceptual Decisions and Modulating Superior Colliculus Activity through the Mouse Posterior Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Retrograde optogenetics reveals sensorimotor convergence within a corticotectal pathway of non-human primates.Current biology : CB · 2026Article
- Learning-dependent 4 Hz synchronization in the posterior striatum, lateral geniculate nucleus, and visual cortex.iScience · 2025Article
- Principal axis of primate basal ganglia in processing cognitive flexibility and habitual stability.Brain : a journal of neurology · 2025Review
- Predicting sugar-sweetened beverage intake from the brain and known risk factors in adolescents.Physiology & behavior · 2025Article
- Retrograde Optogenetics Reveals Functional Convergence within a Corticotectal Pathway of Non-Human Primates.bioRxiv : the preprint server for biology · 2025Article
- A distinct circuit for biasing visual perceptual decisions and modulating superior colliculus activity through the mouse posterior striatum.bioRxiv : the preprint server for biology · 2025Article
- Article
- Safety learning induces postsynaptic potentiation of direct pathway spiny projection neurons in the tail of the striatum.bioRxiv : the preprint server for biology · 2025Article
- Fluorescence detection of dopamine signaling to the primate striatum in relation to stimulus-reward associations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Periaqueductal gray passes over disappointment and signals continuity of remaining reward expectancy.Research square · 2025Article
- Periaqueductal gray passes over disappointment and signals continuity of remaining reward expectancy.bioRxiv : the preprint server for biology · 2024Article
- Neuronal Mechanisms Underlying Face Recognition in Non-human Primates.The Japanese psychological research · 2024Article
- Shifting attention to orient or avoid: a unifying account of the tail of the striatum and its dopaminergic inputs.Current opinion in behavioral sciences · 2024Article
- Implication of regional selectivity of dopamine deficits in impaired suppressing of involuntary movements in Parkinson's disease.Neuroscience and biobehavioral reviews · 2024Review
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the primate basal ganglia, the caudate tail (CDt) encodes the historical values (good or bad) of visual objects (i.e., stable values), and electrical stimulation of CDt evokes saccadic eye movements. However, it is still unknown how output from CDt conveys stable value signals to govern behavior. Here, we apply a pathway-selective optogenetic manipulation to elucidate how such value information modulates saccades. We express channelrhodopsin-2 in CDt delivered by viral vector injections. Selective optical activation of CDt-derived terminals in the substantia nigra pars reticulata (SNr) inhibits SNr neurons. Notably, these SNr neurons show inhibitory responses to good objects. Furthermore, the optical stimulation causes prolonged excitation of visual-saccadic neurons in the superior colliculus (SC), and induces contralateral saccades. These SC neurons respond more strongly to good than to bad objects in the contralateral hemifield. The present results demonstrate that CDt facilitates saccades toward good objects by serial inhibitory pathways through SNr.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.