Evidence map›Paper›PMID 32312912›Full record

ArticleLife science alliance2020

Oncogenic

Marco Gualandi, Maria Iorio, Olivia Engeler, André Serra-Roma, Giuseppe Gasparre, Johannes H Schulte, Daniel Hohl, Olga Shakhova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Sequencing of Cutaneous Squamous Cell Carcinoma Primary Tumors and Patient-Matched Metastases RevealsJID innovations : skin science from molecules to population health · 2022
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Marco GualandiDepartment of Medical Oncology and Hematology, University Hospital Zürich, Zürich, Switzerland.ORCID 0000-0003-1135-8369
Maria IorioDepartment of Medical Oncology and Hematology, University Hospital Zürich, Zürich, Switzerland.
Olivia EngelerDepartment of Medical Oncology and Hematology, University Hospital Zürich, Zürich, Switzerland.
André Serra-RomaDepartment of Medical Oncology and Hematology, University Hospital Zürich, Zürich, Switzerland.ORCID 0000-0001-7312-0589
Giuseppe GasparreDepartment of Medical and Surgical Sciences (DIMEC), Medical Genetics Unit, University of Bologna, Bologna, Italy.
Johannes H SchulteDepartment of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Daniel HohlDepartment of Dermatology and Venereology, Hôpital de Beaumont, Lausanne University Hospital Centre, Lausanne, Switzerland.ORCID 0000-0001-6337-7110
Olga ShakhovaDepartment of Medical Oncology and Hematology, University Hospital Zürich, Zürich, Switzerland olga.shakhova@usz.ch.ORCID 0000-0003-4444-3578
University Hospital of Zurich · CHGerman Cancer Research Center · DEHôpital de Beaumont · CHUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer characterized by increased mortality. Here, we show for the first time that anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase of the insulin receptor superfamily, plays a pivotal role in the pathogenesis of cSCC. Our data demonstrate that the overexpression of the constitutively active, mutated ALK,

Indexed as

OncogenesAnaplastic Lymphoma KinaseAnimalsCarcinogenesisCarcinoma, Squamous CellDisease Models, AnimalHEK293 CellsHumansMiceMice, Inbred C57BLMice, TransgenicMutationSignal TransductionSkin NeoplasmsTransfectionALK protein, humanAlk protein, mouseAnaplastic Lymphoma Kinase

Identifiers

PMID32312912
PMCPMC7184028
OpenAlexW3017292653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.