Evidence map›Paper›PMID 32312751›Full record

ArticleThe Journal of biological chemistry2020

The mRNA encoding the JUND tumor suppressor detains nuclear RNA-binding proteins to assemble polysomes that are unaffected by mTOR.

Gatikrushna Singh, Sarah E Fritz, Bradley Seufzer, Kathleen Boris-Lawrie

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. JUNB and JUND in Urological Cancers: A Literature Review.Current issues in molecular biology · 2025
    Review
  3. Article
  4. Review
  5. Circadian Control of Protein Synthesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  6. Review
  7. Application of Mammalian Nudix Enzymes to Capped RNA Analysis.Pharmaceuticals (Basel, Switzerland) · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. HIV-1 hypermethylated guanosine cap licenses specialized translation unaffected by mTOR.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  16. Review
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Gatikrushna SinghDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, Minnesota 55108.ORCID 0000-0002-9870-5556
Sarah E FritzIntegrated Biomedical Science Graduate Program, Ohio State University, Columbus, Ohio 43210.ORCID 0000-0001-6318-4319
Bradley SeufzerDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, Minnesota 55108.
Kathleen Boris-LawrieDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, Minnesota 55108 kbl@umn.edu.ORCID 0000-0001-6366-6270
University of Minnesota · USThe Ohio State University · US

Funding

Integrative Training in Biomedical SystemsT32GM068412 · NIGMS · OHIO STATE UNIVERSITY · PI PARVIN, JEFFREY D · 2005 to 2020
$2.4M
Inhibitor of FtsZ Polymerization in M. tuberculosisR01AI050470 · NIAID · SOUTHERN RESEARCH INSTITUTE · PI REYNOLDS, ROBERT C · 2002 to 2004
$1.7M
NIAID NIH HHS R01 AI050470NIGMS NIH HHS T32 GM068412
6 · The paper itself

Abstract

One long-standing knowledge gap is the role of nuclear proteins in mRNA translation. Nuclear RNA helicase A (DHX9/RHA) is necessary for the translation of the mRNAs of

Indexed as

AnimalsChlorocebus aethiopsCOS CellsHEK293 CellsHumansMultiprotein ComplexesPolyribosomesProto-Oncogene MasProto-Oncogene Proteins c-junRNA-Binding ProteinsRNA, MessengerTOR Serine-Threonine KinasesTumor Suppressor ProteinsJunD protein, humanMAS1 protein, humanMTOR protein, humanMultiprotein ComplexesProto-Oncogene MasProto-Oncogene Proteins c-junRNA-Binding ProteinsRNA, MessengerTOR Serine-Threonine KinasesTumor Suppressor Proteinscomplex 5'-UTReukaryotic translation initiation factor 4E (eIF4E)mammalian target of rapamycin (mTOR)mTORnon-canonical cap-binding complexpolyribosomepost-transcriptional control element (PCE)RNA binding proteinRNA helicasetumor suppressor gene

Identifiers

PMID32312751
PMCPMC7261793
OpenAlexW3017387797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.