ArticleBMJ open2020
Sex-specific and age-specific characteristics of body composition and its effect on bone mineral density in adults in southern China: a cross-sectional study.
Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- The neuro-skeletal crosstalk: Mechanisms, clinical implications, and smart material interventions.Journal of orthopaedic translation · 2026Review
- Beyond Adiposity: Lean Mass and Bone Mineral Content as Markers of Muscle Weakness and Physical Performance in Older Adults.Medicina (Kaunas, Lithuania) · 2026Article
- Life course adiposity and risk of incident osteoporosis: a prospective cohort study from the UK Biobank.Frontiers in endocrinology · 2026Article
- Age-dependent bone mineral density responses to gender-affirming hormone therapy in transgender individuals: a one-year prospective study.Journal of endocrinological investigation · 2025Observational
- Bone mineral density assessment using radiofrequency echographic multispectrometry (REMS) in patients before and after total hip replacement.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Associations of Markers of Inflammatory Status and Adiposity with Bone Phenotype at Age 60-64 Years: Findings from the MRC National Survey of Health and Development.Calcified tissue international · 2025Article
- Correlation of body compositions and bone mineral density in postmenopausal women with different body mass index.Frontiers in endocrinology · 2025Article
- Bone health and body composition in transgender adults before gender-affirming hormonal therapy: data from the COMET study.Journal of endocrinological investigation · 2024Article
- Characteristics and correlation of body fat distribution and brachial-ankle pulse wave velocity in adults aged 20-59 years: a cross-sectional study.BMC cardiovascular disorders · 2024Article
- The association of body composition and fat distribution with dysmobility syndrome in community-dwelling older adults: Bushehr Elderly Health (BEH) program.BMC musculoskeletal disorders · 2023Article
- Association between lean body mass to visceral fat mass ratio and bone mineral density in United States population: a cross-sectional study.Archives of public health = Archives belges de sante publique · 2023Article
- The Use of Practical Measures to Determine Body Composition of Older People.The Malaysian journal of medical sciences : MJMS · 2023Article
- Different associations between waist circumference and bone mineral density stratified by gender, age, and body mass index.BMC musculoskeletal disorders · 2022Article
- Sarcopenic obesity defined by visceral adiposity was associated with osteoporotic vertebral fracture.Archives of osteoporosis · 2022Article
- The Relationship Between Bone Mineral Density and Body Composition Among Qatari Women With High Rate of Obesity: Qatar Biobank Data.Frontiers in nutrition · 2022Article
- Associations of Fat Mass and Fat Distribution With Bone Mineral Density in Non-Obese Postmenopausal Chinese Women Over 60 Years Old.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study was an attempt to investigate the variation trend of body composition with ageing and explore the association between regional body composition and bone mineral density (BMD).
designCross-sectional study. SETTING AND
participantsA total of 5749 healthy adults aged 20-95 years was recruited from 2004 to 2017. PRIMARY OUTCOME MEASURES: Whole-body lean mass (LM), fat mass (FM), android FM, gynoid FM, appendicular lean mass (ALM) and BMD in the lumbar spine, femoral neck and total hip were obtained by dual-energy X-ray absorptiometry (DXA). The android/gynoid fat mass ratio (A/G FMR) based on DXA scan was calculated as an indicator of adipose distribution. Pearson correlation and multiple linear regression analyses were used to determine the associations between body composition, adipose distribution, and BMD of each skeletal site.
resultsWhole-body FM, percentage of whole-body FM, Android FM and A/G FMR consistently increased with age in both genders, especially in women, and ALM began to decrease in the fifth decade for both men and women. In multivariable linear regression models with age, body mass index, A/G FMR and ALM as predictor variables, ALM was associated with the most BMD variance of all skeletal sites in men (standard β ranged from 0.207 to 0.405, p<0.001), although not the largest but still a positive predictor of BMD in women (standard β ranged from 0.074 to 0.186, p<0.05). A/G FMR was an inverse predictor of BMD at all skeletal sites for women (standard β ranged from -249 to -0.052, p<0.01) but not in men.
conclusionsIn this large cohort of Chinese adults, ALM had a strong positive association with BMD in both genders. A/G FMR as an indicator of central adipose accumulation was inversely associated with BMD in women but not in men.
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