Observational studyCritical care (London, England)2020
Using arterial-venous oxygen difference to guide red blood cell transfusion strategy.
Observational study in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03767127 (Red Blood Cell Transfusion Decision Based on Arterial-venous Oxygen Difference Can Reduce Mortality in Critically Ill Patients), which is not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Red Blood Cell Transfusion Decision Based on Arterial-venous Oxygen Difference Can Reduce Mortality in Critically Ill Patients
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Transfusion thresholds and other strategies for guiding red blood cell transfusion.The Cochrane database of systematic reviews · 2025Pooled it
- Transfusion thresholds for guiding red blood cell transfusion.The Cochrane database of systematic reviews · 2021Pooled it
- Physiological determinants and the red blood cells transfusion decision-making process in non-bleeding critically ill patients: a comprehensive narrative review.Intensive care medicine · 2026Review
- Transfusion in Surgical SAH: Between Guidelines, New Evidence, and Physiology.Neurocritical care · 2026Article
- The challenge of sepsis in older adults in the Emergency Department and intensive care units.Critical care science · 2026Article
- Evaluation of alternative transfusion triggers in hemodynamically stable, non-ventilated cancer patients: a prospective observational study.Scientific reports · 2025Observational
- Physiologic transfusion thresholds, better than using Hb-based thresholds?Blood transfusion = Trasfusione del sangue · 2025Article
- Article
- Alternative blood transfusion triggers: a narrative review.BMC anesthesiology · 2024Review
- Article
- Patient Blood Management, Anemia, and Transfusion Optimization Across Surgical Specialties.Anesthesiology clinics · 2023Review
- Appropriateness of Allogeneic Red Blood Cell Transfusions in Non-Bleeding Patients in a Large Teaching Hospital: A Retrospective Study.Journal of clinical medicine · 2023Article
- Transfusion increased skin blood flow when initially low in volume-resuscitated patients without acute bleeding.Frontiers in medicine · 2023Article
- P(v-a)COBMJ open · 2022Article
- Correction: Using arterial-venous oxygen difference to guide red blood cell transfusion strategy.Critical care (London, England) · 2022Article
- The Impact of Red Blood Cell Transfusion on Blood Lactate in Non-Bleeding Critically Ill Patients-A Retrospective Cohort Study.Journal of clinical medicine · 2022Article
- Review
- Physiologic approach to red blood cell transfusion in non-bleeding critically ill patients.Archives of medical science : AMS · 2022Article
- Transfusion in the mechanically ventilated patient.Intensive care medicine · 2020Review
- Beyond hemoglobin thresholds: A physiology-guided framework for red blood cell transfusion in non-bleeding critically ill patients.Science progressReview
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGuidelines recommend a restrictive red blood cell transfusion strategy based on hemoglobin (Hb) concentrations in critically ill patients. We hypothesized that the arterial-venous oxygen difference (A-V O
methodsA prospective observational study including 177 non-bleeding adult patients with a Hb concentration of 7.0-10.0 g/dL within 72 h after ICU admission. The A-V O
resultsPatients managed with an "appropriate" strategy had lower mortality rates (23/96 [24%] vs. 36/81 [44%]; p = 0.004), and an "appropriate" strategy was independently associated with reduced mortality (hazard ratio [HR] 0.51 [95% CI 0.30-0.89], p = 0.01). There was a trend to less acute kidney injury with the "appropriate" than with the "inappropriate" strategy (13% vs. 26%, p = 0.06), and the Sequential Organ Failure Assessment (SOFA) score decreased more rapidly (p = 0.01). The A-V O
conclusionsIn anemic, non-bleeding critically ill patients, transfusion may be associated with lower 90-day mortality and morbidity in patients with higher A-V O
trial registrationClinicalTrials.gov, NCT03767127. Retrospectively registered on 6 December 2018.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.