Evidence map›Paper›PMID 32312293›Full record

ArticleGenome biology2020

scATAC-pro: a comprehensive workbench for single-cell chromatin accessibility sequencing data.

Wenbao Yu, Yasin Uzun, Qin Zhu, Changya Chen, Kai Tan

Abstract read
In one paragraph

Article in Genome biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Review
  8. Decoding cnidarian cell type gene regulation.Nature ecology & evolution · 2026
    Article
  9. Computational Analyses and Challenges of Single-cell ATAC-seq.Genomics, proteomics & bioinformatics · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wenbao YuCenter for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Yasin UzunCenter for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Qin ZhuGenomics and Computational Biology Graduate Group, University of Pennsylvania, Philadelphia, PA, USA.
Changya ChenCenter for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Kai TanCenter for Childhood Cancer Research, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. tank1@email.chop.edu.

Funding

Data Analysis UnitU2CCA233285 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI TAN, KAI · 2018 to 2023
$13.2M
Mechanisms of endothelial-to-hemogenic transition mediated by Runx1R01HD089245 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI SPECK, NANCY, TAN, KAI · 2017 to 2021
$2.1M
Computational Methods for Unraveling Combinatorial Gene RegulationR01GM108716 · NIGMS · UNIVERSITY OF IOWA · PI TAN, KAI · 2014 to 2017
$1.2M
A TOOLKIT FOR IDENTIFYING CAUSAL VARIANTS IN TRANSCRIPTIONAL ENHANCERSR01GM104369 · NIGMS · UNIVERSITY OF IOWA · PI TAN, KAI · 2014 to 2017
$1.2M
Tools for annotating mutations in the 3D cancer genomeU01CA226187 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI TAN, KAI · 2018 to 2020
$1.2M
NCI NIH HHS CA226187NCI NIH HHS U01 CA226187NCI NIH HHS U2C CA233285NICHD NIH HHS R01 HD089245NIGMS NIH HHS GM104369NIGMS NIH HHS GM108716NIGMS NIH HHS R01 GM108716
6 · The paper itself

Abstract

Single-cell chromatin accessibility sequencing has become a powerful technology for understanding epigenetic heterogeneity of complex tissues. However, there is a lack of open-source software for comprehensive processing, analysis, and visualization of such data generated using all existing experimental protocols. Here, we present scATAC-pro for quality assessment, analysis, and visualization of single-cell chromatin accessibility sequencing data. scATAC-pro computes a range of quality control metrics for several key steps of experimental protocols, with a flexible choice of methods. It generates summary reports for both quality assessment and downstream analysis. scATAC-pro is available at https://github.com/tanlabcode/scATAC-pro.

Indexed as

SoftwareChromatinGene OntologyHumansProtein FootprintingSequence Analysis, DNASingle-Cell AnalysisTranscription FactorsWorkflowChromatinTranscription FactorsBioinformaticsChromatin accessibilityGenomicsSingle cell

Identifiers

PMID32312293
PMCPMC7169039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.