Trial reportCritical care (London, England)2020
Association between incident delirium and 28- and 90-day mortality in critically ill adults: a secondary analysis.
Trial report in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01785290 (Prophylactic Haloperidol Use for Delirium in ICU Patients; a Randomized Placebo-controlled Double-blind Multicentre Trial), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prophylactic Haloperidol Use for Delirium in ICU Patients; a Randomized Placebo-controlled Double-blind Multicentre Trial
Who cites it
21 citing papers in PubMed.
- Substance Use and Delirium Trends in the Critically Ill During the Peri-COVID Period.Critical care explorations · 2026Article
- Association between the confusion assessment method for the intensive care unit (CAM-ICU) and prolonged mechanical ventilation following major cardiac surgery.European journal of medical research · 2026Article
- A comprehensive assessment tool of acute-phase rehabilitation is associated with clinical outcomes in patients after cardiovascular surgery.Heart and vessels · 2025Article
- Delirium at the intensive care unit and long-term survival: a retrospective study.BMC neurology · 2025Observational
- Impact of Delirium Onset and Duration on Mortality in Patients With Cancer Admitted to the ICU.Journal of intensive care medicine · 2024Article
- Promising Effects of Montelukast for Critically Ill Asthma Patients via a Reduction in Delirium.Pharmaceuticals (Basel, Switzerland) · 2024Article
- In-hospital catatonia, delirium, and coma and mortality: Results from the delirium and catatonia prospective cohort investigation.Schizophrenia research · 2024Article
- Early occupational therapy in mechanically ventilated patients improves functional status: Study protocol.The British journal of occupational therapy · 2023Article
- Association between delirium and statin use in patients with congestive heart failure: a retrospective propensity score-weighted analysis.Frontiers in aging neuroscience · 2023Article
- ICU Delirium in Cardiac Patients.Methodist DeBakey cardiovascular journal · 2023Review
- Incidence and interaction factors of delirium as an independent risk of mortality in elderly patients in the intensive units: a retrospective analysis from MIMIC-IV database.Aging clinical and experimental research · 2022Article
- Association of Incident Delirium With Short-term Mortality in Adults With Critical Illness Receiving Mechanical Ventilation.JAMA network open · 2022Article
- The future of intensive care: delirium should no longer be an issue.Critical care (London, England) · 2022Review
- Baseline Anxiety and Depression and Risk for ICU Delirium: A Prospective Cohort Study.Critical care explorations · 2022Article
- Association between early elevated phosphate and mortality among critically ill elderly patients: a retrospective cohort study.BMC geriatrics · 2022Article
- Survival of Frail Elderly with Delirium.International journal of environmental research and public health · 2022Article
- Delirium in critical illness: clinical manifestations, outcomes, and management.Intensive care medicine · 2021Review
- Long-Term Outcomes after Delirium in the ICU: Addressing Gaps in Our Knowledge.American journal of respiratory and critical care medicine · 2021Article
- Natural language processing to assess the epidemiology of delirium-suggestive behavioural disturbances in critically ill patients.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2021Article
- Profiling Delirium Progression in Elderly Patients via Continuous-Time Markov Multi-State Transition Models.Journal of personalized medicine · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundWhile delirium prevalence and duration are each associated with increased 30-day, 6-month, and 1-year mortality, the association between incident ICU delirium and mortality remains unclear. We evaluated the association between both incident ICU delirium and days spent with delirium in the 28 days after ICU admission and mortality within 28 and 90 days.
methodsSecondary cohort analysis of a randomized, double-blind, placebo-controlled trial conducted among 1495 delirium-free, critically ill adults in 14 Dutch ICUs with an expected ICU stay ≥2 days where all delirium assessments were completed. In the 28 days after ICU admission, patients were evaluated for delirium and coma 3x daily; each day was coded as a delirium day [≥1 positive Confusion Assessment Method for the ICU (CAM-ICU)], a coma day [no delirium and ≥ 1 Richmond Agitation Sedation Scale (RASS) score ≤ - 4], or neither. Four Cox-regression models were constructed for 28-day mortality and 90-day mortality; each accounted for potential confounders (i.e., age, APACHE-II score, sepsis, use of mechanical ventilation, ICU length of stay, and haloperidol dose) and: 1) delirium occurrence, 2) days spent with delirium, 3) days spent in coma, and 4) days spent with delirium and/or coma.
resultsAmong the 1495 patients, 28 day mortality was 17% and 90 day mortality was 21%. Neither incident delirium (28 day mortality hazard ratio [HR] = 1.02, 95%CI = 0.75-1.39; 90 day mortality HR = 1.05, 95%CI = 0.79-1.38) nor days spent with delirium (28 day mortality HR = 1.00, 95%CI = 0.95-1.05; 90 day mortality HR = 1.02, 95%CI = 0.98-1.07) were significantly associated with mortality. However, both days spent with coma (28 day mortality HR = 1.05, 95%CI = 1.02-1.08; 90 day mortality HR = 1.05, 95%CI = 1.02-1.08) and days spent with delirium or coma (28 day mortality HR = 1.03, 95%CI = 1.00-1.05; 90 day mortality HR = 1.03, 95%CI = 1.01-1.06) were significantly associated with mortality.
conclusionsThis analysis suggests neither incident delirium nor days spent with delirium are associated with short-term mortality after ICU admission.
trial registrationClinicalTrials.gov, Identifier NCT01785290 Registered 7 February 2013.
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