Evidence map›Paper›PMID 32312174›Full record

ArticleEmerging microbes & infections2020

Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels

Romina Salpini, Arianna Battisti, Lorenzo Piermatteo, Luca Carioti, Olympia E Anastasiou, Upkar S Gill, Domenico Di Carlo, Luna Colagrossi, Leonardo Duca, Ada Bertoli and 24 more

Open access · goldAbstract read
In one paragraph

Article in Emerging microbes & infections, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 13 institutions in 6 countries.

Romina SalpiniDepartment of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
Arianna BattistiBarts Liver Centre, Blizard Institute, Barts and The London SMD, QMUL, London, UK.
Lorenzo PiermatteoDepartment of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
Luca CariotiDepartment of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
Olympia E AnastasiouInstitute of Virology, University-Hospital, University Duisburg-Essen, Essen, Germany.
Upkar S GillBarts Liver Centre, Blizard Institute, Barts and The London SMD, QMUL, London, UK.
Domenico Di CarloPaediatric Clinical Research Center "Romeo and Enrica Invernizzi", University of Milan, Milan, Italy.
Luna ColagrossiMicrobiology and Virology Unit, University of Milan, Milan, Italy.
Leonardo DucaDepartment of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
Ada BertoliDepartment of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
Katia Yu La RosaDepartment of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
Lavinia FabeniLaboratory of Virology, National Institute for Infectious Diseases "Lazzaro Spallanzani" -IRCCS, Rome, Italy.
Alessandra IuvaraMicrobiology and Virology Unit, Tor Vergata University Hospital, Rome, Italy.
Vincenzo MalagninoInfectious Diseases Unit, Tor Vergata University Hospital, Rome, Italy.
Carlotta CervaInfectious Diseases Unit, Tor Vergata University Hospital, Rome, Italy.
Miriam LichtnerPublic Health and Infectious Disease Department, "Sapienza" University, Rome, Italy.
Claudio M MastroianniPublic Health and Infectious Disease Department, "Sapienza" University, Rome, Italy.
Giuseppe Maria De Sanctis"Umberto I" University Hospital, Rome, Italy.
Maurizio PaoloniInfectious Disease Unit, "S.S. Filippo e Nicola" Hospital, Avezzano, Italy.
Massimo MarignaniDepartment of Gastroenterology, "S. Andrea Hospital", Rome, Italy.
Caterina PasquazziDepartment of Gastroenterology, "S. Andrea Hospital", Rome, Italy.
Nerio Iapadre"San Salvatore Hospital", L' Aquila, Italy.
Giustino ParrutiInfectious Disease Unit, Pescara General Hospital, Pescara, Italy.
Jacopo VecchietDepartment of Medicine and Science of Aging, Clinic of Infectious Diseases, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy.
Loredana SarmatiInfectious Diseases Unit, Tor Vergata University Hospital, Rome, Italy.
Massimo AndreoniInfectious Diseases Unit, Tor Vergata University Hospital, Rome, Italy.
Mario AngelicoHepatology Unit, Tor Vergata University Hospital, Rome, Italy.
Sandro GrelliDepartment of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.ORCID https://orcid.org/0000-0003-1028-3203
Patrick T KennedyBarts Liver Centre, Blizard Institute, Barts and The London SMD, QMUL, London, UK.
Jens VerheyenInstitute of Virology, University-Hospital, University Duisburg-Essen, Essen, Germany.
Stefano AquaroDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
Francesca Ceccherini SilbersteinDepartment of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
Carlo Federico PernoDepartment of Oncology and Haemato-oncology, University of Milan, Milan, Italy.
Valentina SvicherDepartment of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy.
University of Rome Tor Vergata · ITQueen Mary University of London · GBUniversity of Milan · ITCTO Andrea Alesini · ITDepartment of Public Health · MMUniversity of Duisburg-Essen · DEAzienda USL di Pescara · ITIstituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITOspedale San Filippo Neri · ITPoliclinico Umberto I · ITSan Salvatore Hospital · ITUniversity of Calabria · ITUniversity of Chieti-Pescara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidences suggest that HBsAg-production varies across HBV-genotypes. HBsAg C-terminus plays a crucial role for HBsAg-secretion. Here, we evaluate HBsAg-levels in different HBV-genotypes in HBeAg-negative chronic infection, the correlation of specific mutations in HBsAg C-terminus with HBsAg-levels

Indexed as

Hepatitis B virusAdultFemaleGenotypeHepatitis B, ChronicHepatitis B Surface AntigensHumansMaleMiddle AgedMutationHepatitis B Surface AntigensHBeAg-negative infectionHBsAg C-terminusHBsAg levelsHBsAg mutationsHBV genotypes

Identifiers

PMID32312174
PMCPMC7269061
OpenAlexW3016491745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.