ArticleEuropean journal of histochemistry : EJH2020
MMP-7 and MMP-9 are overexpressed in the synovial tissue from severe temporomandibular joint dysfunction.
Article in European journal of histochemistry : EJH, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- The therapeutic potential of terpenes in periodontal disease: a systematic review of pre-clinical animal studies.Inflammopharmacology · 2025Pooled it
- The Role of Biomarkers in Temporomandibular Disorders: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Precision Medicine in Temporomandibular Joint Disorders: A Synovial Fluid Biomarker-Based Literature Review.Medicina (Kaunas, Lithuania) · 2026Review
- Temporomandibular joint degeneration arises spontaneously in STR/ort mice and is prevented by targeted aggrecanase inhibition.Osteoarthritis and cartilage open · 2025Article
- The Temporomandibular Joint and the Human Body: A New Perspective on Cross Talk.Dentistry journal · 2024Review
- Causal relationship between hypothyroidism and temporomandibular disorders: evidence from complementary genetic methods.BMC oral health · 2024Article
- Pregnancy related factors and temporomandibular disorders evaluated through the diagnostic criteria for temporomandibular disorders (DC/TMD) axis II: a cross sectional study.BMC oral health · 2024Article
- A Bibliometric Analysis of Research on Temporomandibular Joint Disc Displacement from 1992 to 2022.Healthcare (Basel, Switzerland) · 2023Review
- Prosthetically Guided Orthodontics (PGO): A Personalized Clinical Approach for Aesthetic Solutions Using Digital Technology.Journal of personalized medicine · 2022Article
- Advances in Clinical and Molecular Research of Biomaterials in Dentistry: The New Era for Dental Applications.Journal of clinical medicine · 2022Article
- Inhibition of HMGB1 suppresses inflammation and catabolism in temporomandibular joint osteoarthritis <em>via</em> NF-κB signaling pathway.European journal of histochemistry : EJH · 2022Article
- Impact of Oral Microbiome in Periodontal Health and Periodontitis: A Critical Review on Prevention and Treatment.International journal of molecular sciences · 2022Review
- ATG7 immunohistochemical expression in malignant pleural mesothelioma. A preliminary report.Histology and histopathology · 2021Article
- Role of Photobiomodulation Therapy in Modulating Oxidative Stress in Temporomandibular Disorders. A Systematic Review and Meta-Analysis of Human Randomised Controlled Trials.Antioxidants (Basel, Switzerland) · 2021Review
- Proteomic Expression Profile in Human Temporomandibular Joint Dysfunction.Diagnostics (Basel, Switzerland) · 2021Article
- Anaphylactic Death: A New Forensic Workflow for Diagnosis.Healthcare (Basel, Switzerland) · 2021Article
- Cadmium Toxicity on Chondrocytes and the Palliative Effects of 1α, 25-Dihydroxy Vitamin DFrontiers in veterinary science · 2021Article
- Twenty years of histochemistry in the third millennium, browsing the scientific literature.European journal of histochemistry : EJH · 2020Article
- Histological and Immunofluorescence Study of Discal Ligaments in Human Temporomandibular Joint.Journal of functional morphology and kinesiology · 2020Article
- Evaluation of Imaging Software Accuracy for 3-Dimensional Analysis of the Mandibular Condyle. A Comparative Study Using a Surface-to-Surface Matching Technique.International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Matrix metalloproteinases (MMPs) are tissue-enzymes that play a key role during the remodeling process, such as in inflammatory diseases. MMP-7 and MMP-9 have been shown to be implicated in extracellular matrix homeostasis and in joint disc remodeling. The objective of this study was to determine the relation of MMP-7 and MMP-9 expression with severe temporomandibular joint dysfunction, in particular with anterior disk displacement without reduction (ADDwoR), using an immunohistochemical approach. Therefore, twenty human temporomandibular synovia in the test group and ten in the control group were collected. The results showed there was a statistically significant difference (P<0.001) for morphometric and densitometric analysis of both detected MMPs in control and test groups. In conclusion, MMP-7 and MMP-9 were overexpressed in the synovial tissue of patients with ADDwoR.
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Registered trials
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