Evidence map›Paper›PMID 32311961›Full record

Trial reportMedicine2020

Efficacy and safety of combination of curcuminoid complex and diclofenac versus diclofenac in knee osteoarthritis: A randomized trial.

Dhaneshwar Shep, Chitra Khanwelkar, Prakashchandra Gade, Satyanand Karad

Registry-linked trialOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07238478 (Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of JDS-HF3.0 in Menopause Related Quality of Life Outcomes in Postmenopausal Women), which is not on this map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07238478 narecruitingnot on this mapstarted 2025, after this paper: background citation

Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of JDS-HF3.0 in Menopause Related Quality of Life Outcomes in Postmenopausal Women

TypeinterventionalSponsorBonafide HealthRan2025 to 2026Enrolled250ConditionsJoint Discomfort, Joint Pain, Stiffness, Function, Joint Pain, Hot FlashesArmsJDS-HF3.0, Placebo
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 54 citations in OpenAlex.

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  18. Therapeutic Efficacy of Medicinal Plants with Allopathic Medicine in Musculoskeletal Diseases.International journal of plant, animal and environmental sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Dhaneshwar ShepDepartment of Pharmacology, Krishna Institute of Medical Sciences, Satara.
Chitra KhanwelkarDepartment of Pharmacology, Krishna Institute of Medical Sciences, Satara.
Prakashchandra GadeDepartment of Pharmacology, Dr. Vithalrao Vikhe Patil Foundation's Medical College & Hospital, Ahmednagar.
Satyanand KaradDepartment of Orthopedics, City Care Accident Hospital, Parli Vaijnath, Beed, Maharashtra, India.
Krishna Institute of Medical Sciences · INDr. Vitthalrao Vikhe Patil Foundation’s Medical College · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo compare the efficacy and safety of combination of curcuminoid complex and diclofenac vs diclofenac alone in the treatment of knee osteoarthritis (OA).

methodsIn this randomized trial, 140 patients of knee OA received either curcuminoid complex 500 mg (BCM-95) with diclofenac 50 mg 2 times daily or diclofenac 50 mg alone 2 times daily for 28 days. Patients were assessed at baseline, day 14 and day 28. Primary efficacy measures were Knee injury and OA outcome score (KOOS) subscale at day 14 and day 28. Anti-ulcer effect and patient-physician's global assessment of therapy at day 28 were included as secondary endpoints. Safety after treatment was evaluated by recording adverse events and laboratory investigations.

resultsBoth treatment groups showed improvement in primary endpoints at each evaluation visit. Patients receiving curcuminoid complex plus diclofenac showed significantly superior improvement in KOOS subscales, viz. pain and quality of life at each study visit (P < .001) when compared to diclofenac. Less number of patients required rescue analgesics in curcuminoid complex plus diclofenac group (3%) compared to diclofenac group (17%). The number of patients who required histamine 2 (H2) blockers was significantly less in curcuminoid complex plus diclofenac group compared to diclofenac group (6% vs 28%, respectively; P < .001). Adverse effects were significantly less in curcuminoid complex plus diclofenac group (13% vs 38% in diclofenac group; P < .001). Patient's and physician's global assessment of therapy favored curcuminoid complex plus diclofenac than diclofenac.

conclusionCombination of curcuminoid complex and diclofenac showed a greater improvement in pain and functional capacity with better tolerability and could be a better alternative treatment option in symptomatic management of knee OA.

trial registrationISRCTN, ISRCTN10074826.

Indexed as

Anti-Inflammatory Agents, Non-SteroidalCurcumaDiarylheptanoidsDiclofenacFemaleHistamine H2 AntagonistsHumansMaleMiddle AgedOsteoarthritis, KneePeptic UlcerPhytotherapyPlant ExtractsAnti-Inflammatory Agents, Non-SteroidalDiarylheptanoidsDiclofenacHistamine H2 AntagonistsPlant Extracts

Identifiers

PMID32311961
PMCPMC7220260
OpenAlexW3017032031

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.