ArticleEnvironment international2020
Prenatal exposure to per- and polyfluoroalkyl substances and maternal and neonatal thyroid function in the Project Viva Cohort: A mixtures approach.
Article in Environment international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it, 158 citations in OpenAlex.
- Associations of per- and polyfluoroalkyl substances, polychlorinated biphenyls, organochlorine pesticides, and polybrominated diphenyl ethers with oxidative stress markers: A systematic review and meta-analysis.Environmental research · 2023Pooled it
- Metabolic Signatures of Youth Exposure to Mixtures of Per- and Polyfluoroalkyl Substances: A Multi-Cohort Study.Environmental health perspectives · 2023Pooled it
- Per- and Polyfluoroalkyl Substances (PFAS) in Integrated Crop-Livestock Systems: Environmental Exposure and Human Health Risks.International journal of environmental research and public health · 2021Pooled it
- Pediatric effects of forever chemicals may last for a long time.Pediatric research · 2026Review
- Effects of per- and polyfluoroalkyl substances on maternal thyroid function: a stratified analysis by maternal iodine status and thyroid autoantibody status.BMC pregnancy and childbirth · 2026Article
- Review
- A two-step Bayesian clustering approach to relate PFAS mixture profiles and dietary patterns in early pregnancy.Environmental research · 2026Article
- The Placenta as a Target Organ for Poly- and Perfluoroalkyl Substances (PFASs): Molecular Mechanisms of Toxicity.International journal of molecular sciences · 2026Review
- Effects of Legacy PFAS and Novel Alternatives on Thyroid Function in Mother‒Child Populations: A Systematic Review.Journal of toxicology · 2026Review
- Prenatal PFAS exposure and offspring health: evidence review and implications for intergenerational risk assessment.Frontiers in public health · 2026Review
- Factors affecting thyroid nodule among coal miners: a prospective nested case-control study in Xinjiang, China.Frontiers in public health · 2026Article
- Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Maternal Thyroid Function during Pregnancy in a Cohort with High Familial Likelihood of Autism Spectrum Disorder.Environmental science & technology · 2025Article
- Gestational exposures to mixtures of multiple chemical classes and autism spectrum disorder in the MARBLES study.Environmental research · 2025Article
- In-utero and newborn factors and thyroid cancer incidence in adult women in the Sister Study cohort.British journal of cancer · 2025Observational
- How the public's knowledge, attitudes, and practice intersect with scientific evidence about fluoride.Current problems in pediatric and adolescent health care · 2025Article
- Unveiling the Research Void: Exploring the Reproductive Effects of PFAS Compounds on Male Health.Advances in experimental medicine and biology · 2025Review
- A prospective cohort study of persistent endocrine-disrupting chemicals and perceived stress.American journal of epidemiology · 2024Article
- Systematic Exploration of the Association Between Vitamin A Intakes and Sarcopenia Prevalence in American Adults.Food science & nutrition · 2024Article
- Cross-cutting studies of per- and polyfluorinated alkyl substances (PFAS) in Arctic wildlife and humans.The Science of the total environment · 2024Review
- Associations between per- and polyfluoroalkyl substance exposures and metabolic dysfunction associated steatotic liver disease (MASLD) in adult National Health and Nutrition Examination Survey 2017 to 2018.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundMaternal and neonatal thyroid function is critical for growth and neurodevelopment. Exposure to individual per- and polyfluoroalkyl substances (PFAS) can alter circulating thyroid hormone levels, but few studies have investigated effects of combined exposure to multiple PFAS.
objectivesEstimate associations of exposure to multiple PFAS during early pregnancy with maternal and neonatal thyroid function.
methodsThe study population consisted of 726 mothers and 465 neonates from Project Viva, a Boston, Massachusetts area longitudinal pre-birth cohort. We measured six PFAS [perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoate (PFNA), perfluorohexane sulfonate (PFHxS), 2-(N-ethyl-perfluorooctane sulfonamido)acetate (EtFOSAA), and 2-(N-methyl-perfluorooctane sulfonamido)acetate (MeFOSAA)] and thyroxine (T
resultsHigher concentrations of the PFAS mixture were associated with significantly lower maternal FT
conclusionsThese findings support the hypothesis that there may be combined effects of prenatal exposure to multiple PFAS on maternal and neonatal thyroid function, but the direction and magnitude of these effects may vary across individual PFAS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.