Evidence map›Paper›PMID 32311498›Full record

ReviewBrain, behavior, and immunity2020

The impact of nutrition on COVID-19 susceptibility and long-term consequences.

Michael J Butler, Ruth M Barrientos

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Brain, behavior, and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05220631 (A Technological Intervention to Improve Nutrition Among Older Adult Congregate Meal Participants During COVID-19), which is not on this map. Cited by 265 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
265citing papers in PubMed, 3 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05220631 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

A Technological Intervention to Improve Nutrition Among Older Adult Congregate Meal Participants During COVID-19

TypeinterventionalSponsorThe University of Texas at San AntonioRan2022 to 2026Enrolled369ConditionsNutrition Poor, Physical Inactivity, Social IsolationArmsTechnology intervention, Digital Nutrition Intervention
3 · Its place in the literature

Who cites it

265 citing papers in PubMed, 3 syntheses or guidelines pooled it, 574 citations in OpenAlex.

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205 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Michael J ButlerInstitute for Behavioral Medicine Research, Ohio State University, Columbus, OH, United States.
Ruth M BarrientosInstitute for Behavioral Medicine Research, Ohio State University, Columbus, OH, United States; Department of Psychiatry and Behavioral Health, Ohio State University, Columbus, OH, United States; Chronic Brain Injury Program, Discovery Themes Initiative, The Ohio State University, Columbus, OH, United States; Department of Neuroscience, Ohio State University, Columbus, OH, United States. Electronic address: ruth.barrientos@osumc.edu.
Institute for Behavioral Medicine · USThe Ohio State University · US

Funding

Neuroinflammation, Inflammatory Challenge, and MemoryRF1AG028271 · NIA · UNIVERSITY OF COLORADO · PI BARRIENTOS, RUTH M, MAIER, STEVEN F · 2018 to 2021
$2.4M
Exploring HFD-induced alterations in long-term potentiation in aged hippocampus and amygdalaR03AG067061 · NIA · OHIO STATE UNIVERSITY · PI BARRIENTOS, RUTH M · 2020 to 2021
$156k
NIA NIH HHS R03 AG067061NIA NIH HHS RF1 AG028271
6 · The paper itself

Abstract

While all groups are affected by the COVID-19 pandemic, the elderly, underrepresented minorities, and those with underlying medical conditions are at the greatest risk. The high rate of consumption of diets high in saturated fats, sugars, and refined carbohydrates (collectively called Western diet, WD) worldwide, contribute to the prevalence of obesity and type 2 diabetes, and could place these populations at an increased risk for severe COVID-19 pathology and mortality. WD consumption activates the innate immune system and impairs adaptive immunity, leading to chronic inflammation and impaired host defense against viruses. Furthermore, peripheral inflammation caused by COVID-19 may have long-term consequences in those that recover, leading to chronic medical conditions such as dementia and neurodegenerative disease, likely through neuroinflammatory mechanisms that can be compounded by an unhealthy diet. Thus, now more than ever, wider access to healthy foods should be a top priority and individuals should be mindful of healthy eating habits to reduce susceptibility to and long-term complications from COVID-19.

Indexed as

Adaptive ImmunityBetacoronavirusCoronavirus InfectionsCOVID-19DementiaDiabetes Mellitus, Type 2DietDiet, WesternDisease SusceptibilityHumansImmunity, InnateInflammationNeurodegenerative DiseasesNutritional StatusObesityPandemics

Identifiers

PMID32311498
PMCPMC7165103
OpenAlexW3016981436

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.