ArticleThe Journal of allergy and clinical immunology2020
Cutaneous barrier leakage and gut inflammation drive skin disease in Omenn syndrome.
Erratum issuedOpen access · bronzeAbstract read
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Article in The Journal of allergy and clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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18citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Filaggrin Mutation Status and Prevention of Atopic Dermatitis with Maternal Probiotic Supplementation.Acta dermato-venereologica · 2024Trial
- Dipeptidyl peptidase 3 sets the threshold for immune activation and survival during experimental bacterial infection.Nature communications · 2026Article
- Bridging gut microbiota and polycystic ovary syndrome: the mediating role of metabolites and immune pathways via Mendelian randomization and mediation analysis.Journal of ovarian research · 2026Article
- Advances in research on the mechanisms of anti-inflammation of silybin: a review.Frontiers in immunology · 2026Review
- The brain-gut-skin axis in inflammatory and disfiguring skin diseases: mechanistic insights, clinical correlations, and therapeutic strategies.Frontiers in immunology · 2026Review
- From intestinal immune niches to systemic inflammation: programming cellular plasticity and immune redistribution across organs.Frontiers in immunology · 2026Review
- Engineering Multi-Scale Transdermal Delivery Systems for Atopic Dermatitis: Emerging Insights from the Gut-Skin Axis.International journal of nanomedicine · 2026Review
- Atopic dermatitis in inborn errors of immunity: at the interface of immunodeficiency and immune dysregulation.Immunologic research · 2025Review
- Immunopathological and microbial signatures of inflammatory bowel disease in partial RAG deficiency.The Journal of experimental medicine · 2025Article
- Multiomics dissection of human RAG deficiency reveals distinctive patterns of immune dysregulation but a common inflammatory signature.Science immunology · 2025Article
- Immune cell trafficking: a novel perspective on the gut-skin axis.Inflammation and regeneration · 2024Review
- Role of the gut microbiota and innate immunity in polycystic ovary syndrome: Current updates and future prospects.Journal of cellular and molecular medicine · 2024Review
- Expanded microbiome niches of RAG-deficient patients.Cell reports. Medicine · 2023Article
- Intestinal inflammation alters the antigen-specific immune response to a skin commensal.Cell reports · 2022Article
- RAG deficiencies: Recent advances in disease pathogenesis and novel therapeutic approaches.European journal of immunology · 2021Review
- Gut Microbiota, Probiotics, and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review.Frontiers in immunology · 2021Review
- Innovative Cell-Based Therapies and Conditioning to Cure RAG Deficiency.Frontiers in immunology · 2020Review
- Unraveling the gut-skin axis in atopic dermatitis: exploiting insights for therapeutic strategies.Gut microbesReview
Corrections and comments
- Erratum issuedCorrigenda.2021
Authors and funding
35 authors at 20 institutions in 9 countries.
Rosita RigoniMilan Unit, Institute for Genetic and Biomedical Research (IRGB) National Research Council (CNR), Milan, Italy; Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy.
Elena FontanaHumanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy.
Kerry DobbsLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, Md.
Veronica MarrellaMilan Unit, Institute for Genetic and Biomedical Research (IRGB) National Research Council (CNR), Milan, Italy; Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy.
Valentina TavernitiDepartment of Food, Environmental, and Nutritional Sciences, University of Milan Milan, Italy.
Virginia MainaMilan Unit, Institute for Genetic and Biomedical Research (IRGB) National Research Council (CNR), Milan, Italy; Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy.
Amanda FacoettiHumanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy; Humanitas University, Rozzano, Milan, Italy.
Giovanna D'AmicoCentro Ricerca Tettamanti, Clinica Pediatrica, Università Milano-Bicocca, Monza, Italy.
Waleed Al-HerzDepartment of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait; Allergy and Clinical Immunology Unit, Pediatric Department, Al-Sabah Hospital, Kuwait City, Kuwait.
Mario Ernesto Cruz-MunozFacultad de Medicina, Universidad Autónoma del Estado de Morelos, Cuernavaca, Mexico.
Catharina SchuetzDepartment of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Andrew R GenneryGreat North Children's Hospital, Clinical Resource Building, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
Elizabeth K GarabedianNational Human Genome Research Institute, NIH, Bethesda, Md.
Silvia GilianiDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy; Cytogenetic and Medical Genetics Unit, "A. Nocivelli" Institute for Molecular Medicine, Spedali Civili Hospital, Brescia, Italy.
Deborah DraperLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, Md.
Ghassan DbaiboDepartment of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Raif S GehaDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.
Isabelle MeytsDepartment of Pediatrics, Universitair Ziekenhuis Leuven, University Hospitals Leuven, Leuven, Belgium; Laboratory for Inborn Errors of Immunity, Department of Immunology, Microbiology and Transplantation, Katholieke Universiteit Leuven, Leuven, Belgium.
Thomas TousseynLab for Translational Cell and Tissue Research, Department of Imaging and Pathology, Katholieke Universiteit Leuven, Leuven, Belgium.
Benedicte NevenImagine Institute, Paris Descartes-Sorbonne Paris Cité University, Paris, France; Pediatric Immuno-Hematology Unit, Necker Children Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Despina MoshousImagine Institute, Paris Descartes-Sorbonne Paris Cité University, Paris, France; Pediatric Immuno-Hematology Unit, Necker Children Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Alain FischerImagine Institute, Paris Descartes-Sorbonne Paris Cité University, Paris, France; Pediatric Immuno-Hematology Unit, Necker Children Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Ansgar SchulzDepartment of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.
Andrea FinocchiDepartment of Pediatrics, Children's Hospital Bambino Gesù, Rome, Italy.
Douglas B KuhnsNeutrophil Monitoring Laboratory, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, Md.
Danielle L FinkNeutrophil Monitoring Laboratory, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, Md.
Michail S LionakisFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Md.
Muthulekha SwamydasFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Md.
Simone GuglielmettiDepartment of Food, Environmental, and Nutritional Sciences, University of Milan Milan, Italy.
Julie AlejoLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Md.
Ian A MylesLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, Md.
Stefania PittalugaLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Md.
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, Md. Electronic address: luigi.notarangelo2@nih.gov.
Anna VillaMilan Unit, Institute for Genetic and Biomedical Research (IRGB) National Research Council (CNR), Milan, Italy; Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells, and Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy. Electronic address: villa.anna@hsr.it.
Barbara CassaniMilan Unit, Institute for Genetic and Biomedical Research (IRGB) National Research Council (CNR), Milan, Italy; Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy. Electronic address: barbara.cassani@humanitasresearch.it.
National Institute of Allergy and Infectious Diseases · USIstituti di Ricovero e Cura a Carattere Scientifico · ITCenter for Cancer Research · USFrederick National Laboratory for Cancer Research · USHumanitas University · ITKU Leuven · BENational Institutes of Health · USUniversity of Milan · ITAl-Sabah Hospital · KWAmerican University of Beirut Medical Center · LBAssistance Publique – Hôpitaux de Paris · FRAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITBambino Gesù Children's Hospital · ITHarvard University · USInstitut des Maladies Génétiques Imagine · FRInstitute of Genetic and Biomedical Research · ITNational Human Genome Research Institute · USNewcastle University · GBThe San Raffaele Telethon Institute for Gene Therapy · ITTU Dresden · DE
Funding
Immunopathogenesis of Fungal InfectionsZIAAI001175 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI LIONAKIS, MICHAIL · 2012 to 2025
$23.9MHost Immunity Against BacteriaZIAAI001043 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MYLES, IAN · 2009 to 2025
$18.9MCharacterization of the cellular and molecular bases of inborn errors of immunityZIAAI001222 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NOTARANGELO, LUIGI · 2017 to 2025
$15.2MAbstract
backgroundSevere early-onset erythroderma and gut inflammation, with massive tissue infiltration of oligoclonal activated T cells are the hallmark of Omenn syndrome (OS).
objectiveThe impact of altered gut homeostasis in the cutaneous manifestations of OS remains to be clarified.
methodsWe analyzed a cohort of 15 patients with OS and the 129Sv/C57BL/6 knock-in Rag2
resultsWe show that memory/activated T cells from patients with OS and from the Rag2
conclusionsThese results support the existence of an interplay between gut and skin that can sustain skin inflammation in OS.
Indexed as
AnimalsCohort StudiesDermatitisDisease Models, AnimalDNA-Binding ProteinsGastrointestinal MicrobiomeHumansInflammationIntestinesLymphocyte ActivationMiceMice, Inbred C57BLReceptors, CCR4Severe Combined ImmunodeficiencySkinTh1 CellsCcr4 protein, mouseDNA-Binding ProteinsRag2 protein, mouseReceptors, CCR4chemokinescytokinesdysbiosiserythrodermagut-skin axisimmune-mediated diseaseLPSRAGskin inflammationT cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.