ArticleTrends in biochemical sciences2020
Structural Insights into the Activation of mTORC1 on the Lysosomal Surface.
Article in Trends in biochemical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- [Effects and mechanism of glycine on rat cardiomyocytes pretreated with serum from burned rats].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Article
- [Effects and cell signaling mechanism of glutamine on rat cardiomyocytes intervened with serum from burned rat].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021Article
- The role of metabolic ecosystem in cancer progression - metabolic plasticity and mTOR hyperactivity in tumor tissues.Cancer metastasis reviews · 2021Review
- A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity.Molecular brain · 2021Article
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Authors and funding
3 authors.
Funding
Abstract
Using cryo-electron microscopy and molecular characterization, David Sabatini and colleagues provide crucial new insights that validate and expand their model of how amino acids are sensed and signal at the lysosome to activate mechanistic target of rapamycin complex 1 (mTORC1) and cell growth-regulating processes. This work also reveals new therapeutic opportunities for mTORC1-driven diseases.
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Registered trials
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