Evidence map›Paper›PMID 32310996›Full record

SynthesisPloS one2020

Effects of intravenous dextrose on preventing postoperative nausea and vomiting: A systematic review and meta-analysis with trial sequential analysis.

Chisaki Yokoyama, Takahiro Mihara, Shizuka Kashiwagi, Motokazu Koga, Takahisa Goto

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06726980 (Effects of Dextrose Versus Saline Infusion on Intrathecal Morphine-Induced Postoperative Nausea and Vomiting During Gynecological Abdominal Surgeries), which is not on this map. Cited by 6 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 4 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06726980 phase4not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effects of Dextrose Versus Saline Infusion on Intrathecal Morphine-Induced Postoperative Nausea and Vomiting During Gynecological Abdominal Surgeries: Randomized Controlled Double-blind Study

TypeinterventionalSponsorAssiut UniversityRan2025 to 2026Enrolled63ConditionsGynecological Abdominal SurgeriesArmsdextrose 5%, Dextrose 10%, 0.9% saline
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chisaki YokoyamaDepartment of Anesthesiology and Critical Care Medicine, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.ORCID 0000-0002-8538-1265
Takahiro MiharaDepartment of Anesthesiology and Critical Care Medicine, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.ORCID 0000-0003-0613-511X
Shizuka KashiwagiDepartment of Anesthesiology and Critical Care Medicine, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Motokazu KogaDepartment of Anesthesiology and Critical Care Medicine, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Takahisa GotoDepartment of Anesthesiology and Critical Care Medicine, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Yokohama City University · JPYokohama City University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is reported that postoperative nausea and vomiting, common general anesthesia complications, may be prevented by perioperative intravenous dextrose administration, but with controversial clinical effectiveness.

objectiveTo evaluate perioperative intravenous dextrose for preventing postoperative nausea and vomiting through a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis. DATA SOURCES: MEDLINE, the Cochrane Central Register of Controlled Trials, Embase, Web of Science, clinicaltrials.gov, and the University Hospital Medical Information Network Clinical Trials Registry were searched from inception until 22 June 2019. ELIGIBILITY CRITERIA: Trials investigating intravenous dextrose effects vs. placebos on postoperative nausea and vomiting in patients who underwent general anesthesia.

resultsEleven trials (1,250 patients) were included. All participants were ASA1-2. The nine trials included laparoscopic surgeries, and 92.2% of the participants were women. The timing of dextrose infusion was before, during, and after surgery in three, five, and three trials, respectively. Our results revealed intravenous dextrose administration significantly reduced postoperative nausea, but not vomiting, during early and late postoperative periods (risk ratio [95% confidence interval], early nausea: 0.76 [0.59-0.99], late nausea: 0.65 [0.48-0.89]; early vomiting: 1.00 [0.81-1.25], late vomiting: 0.96 [0.43-2.16]). Evidence quality was downgraded to low because the trial sequential analysis indicated more trials are needed for firm conclusions.

conclusionsCompared with placebos, perioperative intravenous dextrose administration may decrease postoperative nausea but not vomiting.

trial registrationUniversity Hospital Medical Information Network Clinical Trials Registry (registration number: UMIN000030901).

Indexed as

Administration, IntravenousBlood GlucoseDatabases, FactualGlucoseHumansPostoperative Nausea and VomitingRiskBlood GlucoseGlucose

Identifiers

PMID32310996
PMCPMC7170240
OpenAlexW3016811764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.