ArticleeLife2020
A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl
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Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
–field-weighted citation impact
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Who cites it
33 citing papers in PubMed.
- Article
- Database ofKidney international reports · 2026Article
- Molecular mechanism of exchange coupling in CLC chloride/proton antiporters.Nature communications · 2026Article
- A large-scale evolutionary and structural analysis of CLC channels and transporters.Protein science : a publication of the Protein Society · 2025Article
- Molecular simulations meet personalized medicine: The mechanism of action of CLC-5 antiporter and the origin of Dent's disease.PNAS nexus · 2025Article
- Structural basis of ClC-3 transporter inhibition by TMEM9 and PtdIns(3,5)PNature structural & molecular biology · 2025Article
- Multiscale Responsive Kinetic Modeling: Quantifying Biomolecular Reaction Flux under Varying Electrochemical Conditions.Journal of chemical theory and computation · 2025Article
- Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger.Nature communications · 2024Article
- Multiscale Responsive Kinetic Modeling: Quantifying Biomolecular Reaction Flux under Varying Electrochemical Conditions.bioRxiv : the preprint server for biology · 2024Article
- Structural basis of pH-dependent activation in a CLC transporter.Nature structural & molecular biology · 2024Article
- Macromolecular Crowding, Phase Separation, and Homeostasis in the Orchestration of Bacterial Cellular Functions.Chemical reviews · 2024Review
- Article
- Fluoride Transport and Inhibition Across CLC Transporters.Handbook of experimental pharmacology · 2024Article
- Efficient determination of the accessible conformation space of multi-domain complexes based on EPR PELDOR data.Journal of biomolecular NMR · 2023Article
- CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism.bioRxiv : the preprint server for biology · 2023Article
- Molecular basis of ClC-6 function and its impairment in human disease.Science advances · 2023Article
- Molecular mechanism underlying regulation of Arabidopsis CLCa transporter by nucleotides and phospholipids.Nature communications · 2023Article
- Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42.Nature communications · 2023Article
- A cooperative knock-on mechanism underpins Ca2+-selective cation permeation in TRPV channels.The Journal of general physiology · 2023Article
- The role of conformational change and key glutamic acid residues in the ClC-ec1 antiporter.Biophysical journal · 2023Article
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Authors and funding
9 authors.
Tanmay S Chavan *Department of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, United States.
Ricky C Cheng *Department of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, United States.ORCID 0000-0002-5667-6945
Tao JiangNIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, United States.
Irimpan I MathewsStanford Synchrotron Radiation Lightsource, Stanford University, Menlo Park, United States.
Richard A SteinDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, United States.
Antoine KoehlDepartment of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, United States.
Hassane S MchaourabDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, United States.
Emad TajkhorshidNIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, United States.ORCID 0000-0001-8434-1010
Merritt MadukeDepartment of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, United States.ORCID 0000-0001-7787-306X
Funding
X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6MWHOLE CELL SIMULATIONP41GM104601 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI TAJKHORSHID, EMAD · 2012 to 2021
$19.0MMechanisms of CLC Transporters and Channels:R01GM113195 · NIGMS · STANFORD UNIVERSITY · PI MADUKE, MERRITT C · 2016 to 2024
$4.0MAmerican Heart Association 17POST33670553Extreme Science and Engineering Discovery Environment MCA06N060NIGMS NIH HHS P41 GM103393NIGMS NIH HHS P41 GM104601NIGMS NIH HHS R01 GM113195U.S. Department of Energy DE-AC02-06CH11357
Abstract
Among coupled exchangers, CLCs uniquely catalyze the exchange of oppositely charged ions (Cl
Indexed as
AntiportersChloridesCrystallography, X-RayEscherichia coli ProteinsIon TransportMutationProtein ConformationProton PumpsProtonsSpectrum AnalysisAntiportersChloridesCLC-ec1 protein, E coliEscherichia coli ProteinsProton PumpsProtonsantiporterchloridecrystallographyDEER spectroscopyE. coliMD simulationsmembrane exchangermolecular biophysicsstructural biology
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.